Publications de Erica Martin-Williams

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Anthony Christopher Davison, Theo Lasser, Martin Villiger, Dimitri Nestor Alice Van De Ville, Anne Grapin-Botton, Corinne Berclaz, Joan Goulley, Erica Martin-Williams, Arno Pino Bouwens

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Real-time full field laser Doppler imaging

Marcel Leutenegger, Theo Lasser, Antonio Lopez, Tyler Nerton Thacher, Erica Martin-Williams

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm² with 480 × 480 pixels per frame at a rate ...

2011

Functional optical coherent imaging platform for medical application e.g. neurosurgery, has active camera unit that captures image of specific region of test subject after transmitting stimulus signals

Iwan Märki, Marcel Leutenegger, Theo Lasser, Martin Villiger, Michael Friedrich, Dimitri Nestor Alice Van De Ville, Erica Martin-Williams

The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected ...

2010

Method for displaying field e.g. tumor, of brain of human patient during surgery of brain, involves acquiring topography data representing topography of field, where output image is displayed based on topography data

Marcel Leutenegger, Theo Lasser, Antonio Lopez, Erica Martin-Williams

NOVELTY - The method involves illuminating a field (11) of brain (13) of a patient for acquiring an image sequence of the field. The field is illuminated after stimulating the patient for acquiring another image sequence. The image sequences are evaluated ...

2010

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Martin Villiger, Anne Grapin-Botton, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

Object i.e. aneurysm, examining method for brain of patient, involves evaluating sequence of images by associating pixels with analysis image value depending on temporal changes of image values of pixels in specified frequency range

Marcel Leutenegger, Theo Lasser, Antonio Lopez, Michael Friedrich, Erica Martin-Williams

NOVELTY - The method involves illuminating an object i.e. aneurysm, with measuring light with wavelengths ranging from 790 nanometer to 820 nanometer, and recording a sequence of images (21, 22) i.e. white light image, of the illuminated object. The sequen ...

2009

Laser Doppler imaging for intraoperative human brain mapping

Marcel Leutenegger, Michaël Unser, Theo Lasser, Dimitri Nestor Alice Van De Ville, Rainer Leitgeb, Erica Martin-Williams

The identification and accurate location of centers of brain activity are vital both in neuro-surgery and brain research. This study aimed to provide a non-invasive, non-contact, accurate, rapid and user-friendly means of producing functional images intrao ...

Elsevier2009

See the Brain at Work—Intraoperative Laser Doppler Functional Brain Imaging

Marcel Leutenegger, Michaël Unser, Theo Lasser, Antonio Lopez, Dimitri Nestor Alice Van De Ville, Rainer Leitgeb, Erica Martin-Williams

During open brain surgery we acquire perfusion images non-invasively using laser Doppler imaging. The regions of brain activity show a distinct signal in response to stimulation providing intraoperative functional brain maps of remarkably strong contrast. ...

2009

Method for displaying field of brain of patient during brain surgery involves determining output image from analysis image values and displaying output image

Marcel Leutenegger, Theo Lasser, Antonio Lopez, Erica Martin-Williams

NOVELTY - The display method involves evaluating the sequence of images by: associating a first analysis image value to pixels in the first sequence of images to which pixels of same locations of the field (11) are imaged, respectively; associating a secon ...

2008