Publications de Benjamin Boutrel

Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression

Pierre Magistretti, Jean-Marie Petit, Benjamin Boutrel, Daniel Sciarra, Jean-René Cardinaux

Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy b ...

Springer Nature2017

A preclinical model for identifying rats at risk of alcohol use disorder

Pierre Magistretti, Benjamin Boutrel

Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains o ...

Springer Nature2017

A key role of glycogen derived lactate from astrocytes in cocaine associated memories

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot, Anthony Carrard

Wiley2017

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot

The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons active ...

Wiley-Blackwell2016

A Role for Lactate in the Consolidation of Drug-Related Associative Memories

Pierre Magistretti, Benjamin Boutrel

Elsevier2016

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

Jean-Luc Martin, Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot, Anthony Carrard

A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memo ...

Nature Publishing Group2015

Involvement of Astrocyte-derived Lactate in the Formation and Maintenance of Cocaine Seeking Behavior

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot

Elsevier Science Inc2014