Publications de Léonie Asboth

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Jocelyne Bloch, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Cathal John Harte

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Léonie Asboth, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Nicolas Hankov, Katia Galan, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Jimmy James Ravier, Thomas Haynes Hutson, Viviana Aureli

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Neuromodulation/neurostimulation system for controlling a respiratory function

Vincent Delattre, Léonie Asboth, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system c ...

2024

Walking naturally after spinal cord injury using a brain-spine interface

Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Robin Jonathan Demesmaeker, Félix Antoine Martel, Laure Coquoz, Jocelyne Bloch, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Molywan Vat, Carmina Andrea Galvez Solano, Cathal John Harte, Valeria Spagnolo, Grégory Didier Dumont, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

NATURE PORTFOLIO2023

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Tomislav Milekovic, Léonie Asboth, Grégoire Courtine, Eduardo Martin Moraud, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Jordan Squair

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Léonie Asboth, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Noaf Salah Ali Alwahab, Ivan Furfaro, Ileana Ozana Jelescu, Andreas Rowald, Claudia Kathe, Valentina Marie Paggi, Jimmy James Ravier, Kyungjin Kim, Thomas Haynes Hutson

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Léonie Asboth, Nawal Noëlle Kinany, Salif Axel Komi, Silvestro Micera, Grégoire Courtine, Miroslav Caban, Quentin Barraud, Marco Capogrosso, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Nathan Antoine Greiner, Jocelyne Bloch, Sergio Daniel Hernandez, Laura Ann McCracken, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Carmina Andrea Galvez Solano

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

Targeted dorsal root entry zone stimulation alleviates pain due to meralgia paresthetica

Léonie Asboth, Grégoire Courtine, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch, Jimmy James Ravier, Molywan Vat, Viviana Aureli

Objective. Meralgia paresthetica (MP) is a mononeuropathy of the exclusively sensory lateral femoral cutaneous nerve (LFCN) that is difficult to treat with conservative treatments. Afferents from the LFCN enter the spinal cord through the dorsal root entry ...

IOP Publishing Ltd2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

Léonie Asboth, Maxime Berney, Grégoire Courtine, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch, Sergio Daniel Hernandez, Jordan Squair, Grégory Didier Dumont, Suje Amir

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood press ...

MASSACHUSETTS MEDICAL SOC2022

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Bernard Schneider, Léonie Asboth, Grégoire Courtine, Janine Beauparlant, Lucia Florinda Friedli Wittler, Selin Anil, Quentin Barraud, Cristina Martinez Gonzalez, Julie Kreider, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Galyna Pidpruzhnykova, Elodie Rey, Polina Shkorbatova

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Optical cuff for optogenetic control of the peripheral nervous system

Léonie Asboth, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Loïc Sottas, Grégoire Courtine

Objective. Nerves in the peripheral nervous system (PNS) contain axons with specific motor, somatosensory and autonomic functions. Optogenetics offers an efficient approach to selectively activate axons within the nerve. However, the heterogeneous nature o ...

2018

Cortico-reticulo-spinal circuits mediate functional recovery after spinal cord contusion

Léonie Asboth

After a spinal cord injury (SCI), only half of affected individuals regain voluntary control of leg movements below the level of the lesion. Anatomical, electrophysiological and imaging data revealed that even the most severe forms of SCI usually spare a s ...

EPFL2017

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Léonie Asboth, Jérôme Gandar, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Rubia van den Brand, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Julie Kreider, Laetitia Danielle Philippine Baud, Andrea Mortera, Jocelyne Bloch

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

A neurorobotic platform for locomotor prosthetic development in rats and mice

Léonie Asboth, Grégoire Courtine, Joachim von Zitzewitz, Laetitia Danielle Philippine Baud, Nicolas Francis Fumeaux

Objectives. We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. Approach. We interfaced a large-scale robotic structure actuate ...

Institute of Physics2016

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Tomislav Milekovic, Léonie Asboth, Jérôme Gandar, Nicolas Vachicouras, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015