Publications de Françoise Borcard

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Françoise Borcard, Léo Bühler, François Rémi Pierre Noverraz, Virginia Crivelli, Solène Marcelle Françoise Marie Passemard

Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Compounds for functionalizing biomaterials

Sandrine Gerber, Françoise Borcard

The present invention provides compounds suitable for functionalizing biomaterials, in particular prosthetics and implant materials, functionalized biomaterials, and methods for synthesizing the compound. The compounds contain an anchoring group, a group f ...

2014

Alginate-PEG biomaterial for cell microencapsulation and xenotransplantation

Jutta Christine Wandrey, Yannick Müller, Redouan Mahou, Françoise Borcard

Wiley-Blackwell2013

Chemical Functionalization of Bioceramics for the Development of Bone Implants

Françoise Borcard

EPFL2013

Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts

Sandrine Gerber, Phally Kong, Françoise Borcard, Céline Marie Anne Journot, Davide Städler

Surface functionalization of hydroxyapatite (HA) and β-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible co ...

Swiss Chemical Soc2013

Synthesis of bone-like structured foams

Sandrine Gerber, Françoise Borcard

Here we present a processing route to produce multi-structured ceramic foams based on the combination of particle-stabilized foams with polymeric sponges to produce positive and negative templating structures. Polyester sponges are infiltrated with freshly ...

Elsevier Sci Ltd2013

Surface Functionalisation of Alumina Ceramic Foams with Organic Ligands

Sandrine Gerber, Vincent Laporte, Françoise Borcard, Pascal Miéville, Marc Anthony Caporini

Different anchoring groups have been studied with the aim of covalently binding organic linkers to the surface of alumina ceramic foams. The results suggested that a higher degree of functionalisation was achieved with a pyrogallol derivative - as compared ...

2012

Chemical functionalization of bio-ceramics to enhance endothelial cells adhesion for tissue engineering

Sandrine Gerber, Françoise Borcard, Davide Städler

To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gall ...

American Chemical Society2012

Functionalization of microstructured open-porous bio-ceramic scaffolds with human fetal cells

Sandrine Gerber, Corinne Scaletta, Françoise Borcard, Davide Städler

Bone substitute materials allowing trans-scaffold migration and in-scaffold survival of human bone-derived cells are mandatory for development of cell-engineered permanent implants to repair bone defects. In this study, we evaluated the influence on human ...

American Chemical Society2012

Covalent cell surface functionalization of human fetal osteoblasts for tissue engineering

Sandrine Gerber, Aurélien Godinat, Corinne Scaletta, Françoise Borcard, Davide Städler

The chemical functionalization of cell-surface proteins of human primary fetal bone cells with hydrophilic bioorthogonal intermediates was investigated. Toward this goal, chemical pathways were developed for click reaction-mediated coupling of alkyne deriv ...

2011

Fractional Spin-Labeling of Polymers for Enhancing NMR Sensitivity by Solvent-Free Dynamic Nuclear Polarization

Andrzej Sienkiewicz, Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Françoise Borcard, Pascal Miéville, Marc Anthony Caporini

Wiley-Blackwell2011

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Pierre Vogel, Claudia Bello, Matthias Baud, Françoise Borcard

New oxathiazinane dioxides have been derived from D- and L-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane- 3,3-dioxide showed a c ...

2010