Publications de Jérôme Gandar

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Léonie Asboth, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Noaf Salah Ali Alwahab, Ivan Furfaro, Ileana Ozana Jelescu, Andreas Rowald, Claudia Kathe, Valentina Marie Paggi, Jimmy James Ravier, Kyungjin Kim, Thomas Haynes Hutson

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation

Jérôme Gandar, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Xiaoyang Kang

2020

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Jérôme Gandar

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

EPFL2019

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Jérôme Gandar, Stéphanie Lacour, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Two-phase calibration of a neuroprosthetic system

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, Fabien Bertrand Paul Wagner

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018

Long-term usability and bio-integration of polyimide-based intraneural stimulating electrodes

Sophie Marie Marthe Wurth, Jérôme Gandar, Nawal Noëlle Kinany, Silvestro Micera, Grégoire Courtine, Stanisa Raspopovic, Quentin Barraud, Alessandra Piersigilli, Marco Capogrosso, Natalia Pavlova, Jacopo Rigosa, Polina Shkorbatova

Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their us ...

Elsevier Sci Ltd2017

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Tomislav Milekovic, Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Elodie Rey, Jocelyne Bloch

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Léonie Asboth, Jérôme Gandar, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Rubia van den Brand, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Julie Kreider, Laetitia Danielle Philippine Baud, Andrea Mortera, Jocelyne Bloch

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Tomislav Milekovic, Léonie Asboth, Jérôme Gandar, Nicolas Vachicouras, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

A real-time platform for studying the modulatory capacity of epidural stimulation after spinal cord injury

Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko

Epidural electrical stimulation (EES) showed promises to improve standing and walking after neurological disorders. To date, EES has been delivered continuously, although time-dependent stimulations would likely be more efficient to activate specific subse ...

Ieee2013