Publications de Xile Hu | EPFL Graph Search

Encapsulated Co–Ni alloy boosts high-temperature CO2 electroreduction

Jeremy Luterbacher, Xile Hu, Wenhao Ren, Seongmin Jin

Electrochemical CO 2 reduction into chemicals and fuels holds great promise for renewable energy storage and carbon recycling 1–3 . Although high-temperature CO 2 electroreduction in solid oxide electrolysis cells is industrially relevant, current catalyst ...

Springer Science and Business Media LLC2025

Artificial Metalloenzymes with Two Catalytic Cofactors for Tandem Abiotic Transformations

Florence Pojer, Xile Hu, Kelvin Ka Ching Lau, Weijin Wang

Artificial metalloenzymes (ArMs) enable the integration of abiotic cofactors within a native protein scaffold, allowing for non-natural catalytic activities. Previous ArMs, however, have primarily relied on single cofactor systems, limiting them to only on ...

Wiley-VCH Verlag GmbH2025

Anion Exchange Membrane Water Electrolysis at 10 A ⋅ cm−2 Over 800 Hours

Xile Hu, Ariana Serban, Yiwei Zheng

Anion exchange membrane water electrolyzer (AEMWE) is a potentially cost-effective technology for green hydrogen production. Although the normal current densities of AEMWEs are below 3 A ⋅ cm−2, operating them at higher current densities represents an effi ...

Wiley-VCH Verlag GmbH2025

Encapsulated alloy catalysts and their methods of preparation

Xile Hu

The present invention relates to a method for preparing a catalyst comprising the steps of a. dissolving two or more alloy metal salts, b. adding at least one chelating agent and at least one stabilising agent, forming a sol, c. adding an encapsulant to ...

2025

Enantioconvergent Cobalt‐Catalyzed Hydroalkylation for the Construction of Fluoro‐, Chloro‐, and Trifluoromethyl Stereogenic Centers

Xile Hu

Organic compounds containing a chiral, halogenated aliphatic carbon center are useful in medicinal chemistry, but their enantioselective synthesis remains difficult. Here we develop a general approach to access these compounds through cobalt‐catalyzed hydr ...

Wiley2025

Operando Nanoscale Characterization Reveals Fe Doping of Ni Oxide Enhances Oxygen Evolution Reaction via Fragmentation and Formation of Dual Active Sites

Magalí Alejandra Lingenfelder, Xile Hu, Karla Banjac, Seunghwa Lee, Yunchang Liang, Victor Carle Adrien Boureau

Efficient catalytic water splitting demands advanced catalysts to improve the slow kinetics of the oxygen evolution reaction (OER). Earth-abundant transition metal oxides show promising OER activity in alkaline media. However, most experimental information ...

2025

Strain by metal nitrides accelerates oxygen reduction

Xile Hu

Scrutinizing the metal nitride/oxide interface reveals the chemical origin of the enhanced oxygen reduction activity of metal nitrides. ...

NATURE PORTFOLIO2024

Field-enhanced CO electroreduction in membrane electrolyzers at a dehydrated interface

Xile Hu, Miyeon Chang, Wenhao Ren, Nanjun Chen

Zero-gap membrane electrode assembly (MEA) CO electrolyzer stands as a promising technology for circular carbon economy. However, current CO electrolyzers are energetically inefficient when operating at ampere-level current densities. Here, by analyzing th ...

2024

Regiodivergent and Enantioselective Synthesis of Cyclic Sulfones via Ligand-Controlled Nickel-Catalyzed Hydroalkylation

Xile Hu, Deyun Qian, Chao Fan

Cyclic sulfones have demonstrated important applications in drug discovery. However, the catalytic and enantioselective synthesis of chiral cyclic sulfones remains challenging. Herein, we develop nickel-catalyzed regiodivergent and enantioselective hydroal ...

Wiley-VCH Verlag GmbH2024

Nickel-Catalyzed Enantio- and Diastereoselective Synthesis of Fluorine-Containing Vicinal Stereogenic Centers

Xile Hu, Lara Lavrencic

The construction of fluorinated architectures has been a topic of interest to medicinal chemists due to their unique ability to improve the pharmacokinetic properties of bioactive compounds. However, the stereoselective synthesis of fluoro-organic compound ...

2024

Fluorinated polyaromatics with linear, branched or crosslinked structure for anion exchange membranes and ionomers

Xile Hu, Xingyu Wu, Nanjun Chen

The present specification relates to a fluorinated polyaromatic polymer comprising • at least one fluorinated unit FU of formula (I) and • at least one cationic unit CU of formula B or C. ...

2024

Engineered Phenylalanine Ammonia-Lyases for the Enantioselective Synthesis of Aspartic Acid Derivatives

Xile Hu, Ivan Buslov, Yoan Désiré Duhoo

Biocatalytic hydroamination of alkenes is an efficient and selective method to synthesize natural and unnatural amino acids. Phenylalanine ammonia-lyases (PALs) have been previously engineered to access a range of substituted phenylalanines and heteroaryla ...

Wiley-VCH Verlag GmbH2024

An oxide-promoted, self-supported Ni4Mo catalyst for high current density anion exchange membrane water electrolysis

Xile Hu, Nanjun Chen, Ariana Serban

Anionic exchange membrane (AEM) water electrolyzers are emerging as a cost-effective technology for green hydrogen production. However, state-of-the-art AEM electrolyzers rely on platinum group metal (PGM) catalysts for the hydrogen evolution reaction (HER ...

ROYAL SOC CHEMISTRY2024

Nickel molybdenum catalysts and their methods of preparation

Xile Hu, Ariana Serban

The present invention relates to method for the synthesis of a transition metal catalyst consisting of electrodeposition on a substrate electrode from an electrolyte solution comprising at least one transition metal precursor, wherein the electrodeposition ...

2024

Deoxygenative Transformation of Alcohols via Phosphoranyl Radical from Exogenous Radical Addition

Xile Hu, Tao Xu, Chao Fan

A general approach to the direct deoxygenative transformation of primary, secondary, and tertiary alcohols has been developed. It undergoes through phosphoranyl radical intermediates generated by the addition of exogenous iodine radical to trivalent alkoxy ...

Wiley-VCH Verlag GmbH2024

Well-Defined Co2 Dual-Atom Catalyst Breaks Scaling Relations of Oxygen Reduction Reaction

Xile Hu, Yiwei Zheng

The 4-electron oxygen reduction reaction (ORR) under alkaline conditions is central to the development of non-noble metal-based hydrogen fuel cell technologies. However, the kinetics of ORR are constrained by scaling relations, where the adsorption free en ...

AMER CHEMICAL SOC2024

A redox-responsive prodrug for tumor-targeted glutamine restriction

Xile Hu, Daniel Ortiz Trujillo, Li Tang, Céline Jasmin Prange, Bing Feng

Modulating the metabolism of cancer cells, immune cells, or both is a promising strategy to potentiate cancer immunotherapy in the nutrient-competitive tumor microenvironment. Glutamine has emerged as an ideal target as cancer cells highly rely on glutamin ...

Elsevier2024

6-diazo-5-oxo-l-norleucine prodrugs

Xile Hu, Li Tang, Céline Jasmin Prange

The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

2024

Copper-Catalyzed Benzylic Functionalization of Lignin-Derived Monomers

Xile Hu, Lara Lavrencic

Within the field of lignin biorefining, significant research effort has been dedicated to the advancement of catalytic methods for lignocellulose depolymerization. However, another key challenge in lignin valorization is the conversion of the obtained mono ...

WILEY-V C H VERLAG GMBH2023

Fluorinated Poly(aryl piperidinium) Membranes for Anion Exchange Membrane Fuel Cells

Harm-Anton Klok, Xile Hu, Xingyu Wu, Nanjun Chen

Anion-exchange-membrane fuel cells (AEMFCs) are a cost-effective alternative to proton-exchange-membrane fuel cells (PEMFCs). The development of high-performance and durable AEMFCs requires highly conductive and robust anion-exchange membranes (AEMs). Howe ...

Wiley-V C H Verlag Gmbh2023