Publications de Léo Bühler | EPFL Graph Search

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Sandrine Gerber, Léo Bühler, Qixing Zhang, Yi Wang

Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...

2022

Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters

Sandrine Gerber, Léo Bühler, Luca Szabó

Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation to treat type 1 diabetes patients. We isolated ICC from pancreata of 14 days old juvenile piglets and characterized their maturation by immuno ...

2021

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Sandrine Gerber, Daniel Ortiz Trujillo, Léo Bühler, François Rémi Pierre Noverraz, Luca Szabó

The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well- ...

2018

Hydrogels based on functionalized polysaccharides

Jutta Christine Wandrey, Sandrine Gerber, Léo Bühler, Solène Marcelle Françoise Marie Passemard

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine. ...

2018

Beneficial effects of human mesenchymal stromal cells on porcine hepatocytes viability and albumin secretion

Sandrine Gerber, Léo Bühler, Solène Marcelle Françoise Marie Passemard, Aurélien Thomas

Wiley2017

Hydrogels based on functionalized polysaccharides

Jutta Christine Wandrey, Sandrine Gerber, Léo Bühler, Solène Marcelle Françoise Marie Passemard

The present invention relates to a functionalized hydrogel network grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine. ...

Technology Transfer Office EPFL, Swiss Federal Institute of Intellectual Property2016

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Françoise Borcard, Léo Bühler, François Rémi Pierre Noverraz, Virginia Crivelli, Solène Marcelle Françoise Marie Passemard

Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Human Mesenchymal Stromal Cells Improve Survival And Function Of Pancreatic Islets By Cell-To-Cell Contact

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Léo Bühler, Solène Marcelle Françoise Marie Passemard

Wiley-Blackwell2015

Encapsulated mesenchymal stem cells xenotransplanted in mice produce anti-inflammatory cytokines and delay liver fibrosis

Jutta Christine Wandrey, Yannick Müller, Redouan Mahou, Léo Bühler

Wiley-Blackwell2013