Publications de Matthias Alexander Sokrates Stein

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Matthias Alexander Sokrates Stein, Johan Auwerx, Julien Weber, Tasneem Arsiwala

Aims: Sirtuin 6 (Sirt6) is a NAD(+)-dependent deacetylase that plays a key role in DNA repair, inflammation and lipid regulation. Sirt6-null mice show severe metabolic defects and accelerated aging. Macrophage-foam cell formation via scavenger receptors is ...

2020

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Elena Katsyuba, Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Alessia Perino, Karim Laurent Gariani, Vera Monica Lemos Da Silva, Pooja Jha, Jun Yong Kim

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Dongryeol Ryu, Maaike Hélène Oosterveer, Pan Xu, Xu Wang, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) ...

Amer Soc Clinical Investigation Inc2017

Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator

Matthias Alexander Sokrates Stein

Oxford Univ Press2017

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Arnaud Comment, Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Norman Lionel Moullan, Dongryeol Ryu, Maaike Hélène Oosterveer, Emine Can, Pan Xu, Xu Wang, Hadrien Charles Edouard Demagny

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...

Cold Spring Harbor Laboratory2016

Molecular basis for the regulation of the nuclear receptor LRH-1

Matthias Alexander Sokrates Stein, Kristina Schoonjans

Liver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in the enterohepatic system. While initially described as an orphan NR, recent studies sugges ...

Current Biology Ltd2015

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis

Matthias Alexander Sokrates Stein, Kristina Schoonjans

Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involvi ...

Nature Publishing Group2015

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Giuseppe Lo Sasso, Hongbo Zhang, Alessia Perino

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Alessia Perino

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Chikage Mataki, Dongryeol Ryu, Maaike Hélène Oosterveer, Pan Xu, Keir Joe Menzies, Alessia Perino, Xu Wang, Vera Monica Lemos Da Silva

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014