Publications de Laure Menin | EPFL Graph Search

Top-Down and Middle-Down Mass Spectrometry of Antibodies

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional c ...

Elsevier BV2025

Rapid Untargeted Puff-by-Puff Analysis of (Electronic) Cigarette Emissions by Concentric Dielectric Barrier Discharge Ionisation Mass Spectrometry

Luc Patiny, Laure Menin, Natalia Gasilova, Maria Pavlou

Despite the soaring popularity of e-cigarettes among teenagers and young adults, our understanding of the full extent of their health hazards have remained limited. This is due to the vast complexities of e-cigarette aerosols and the difficulty in their fu ...

2024

Adding Color to Mass Spectra of Biopolymers: Charge Determination Analysis (CHARDA) Assigns Charge State to Every Ion Peak

Yury Tsybin, Laure Menin, Anton Kozhinov, Natalia Gasilova, Konstantin Nagornov

Traditionally, mass spectrometry (MS) output is the ion abundance plotted versus the ionic mass-to-charge ratio m/z. While employing only commercially available equipment, Charge Determination Analysis (CHARDA) adds a third dimension to MS, estimating for ...

Amer Chemical Soc2024

BaiJ and BaiB are key enzymes in the chenodeoxycholic acid 7a-dehydroxylation pathway in the gut microbe Clostridium scindens ATCC 35704

Rizlan Bernier-Latmani, Laure Menin, Karin Lederballe Meibom, Solenne Anne Marie Marion, Théo Nass, Eduard Vico Oton, Colin Volet

Bile acid transformation is a common gut microbiome activity that produces secondary bile acids, some of which are important for human health. One such process, 7α-dehydroxylation, converts the primary bile acids, cholic acid and chenodeoxycholic acid, to ...

2024

Dielectric barrier discharge ionization procures characteristic adducts of polyfluoroalkyl substances (PFAS) amenable by gas chromatography-mass spectrometry

Laure Menin, Natalia Gasilova

Fluorotelomer alcohols (FTOHs) and acrylates (FTACs) have been reported as precursors of perfluoroalkyl acids and are known to contaminate biotic and abiotic compartments. Here, a detailed study was carried out for assessing the capability of dielectric ba ...

2024

The Antioxidant and Proapoptotic Effects of Sternbergia clusiana Bulb Ethanolic Extract on Triple-Negative and Estrogen-Dependent Breast Cancer Cells In Vitro

Laure Menin, Natalia Gasilova, Maria Younes

Background: Sternbergia clusiana belongs to the Amaryllidaceae family and is recognized for the valuable biological activity of its major bioactive compounds. The aim of the current is to evaluate the anticancer effects of the ethanolic bulb extract of Ste ...

MDPI2023

Tyrosine bioconjugation with hypervalent iodine

Jérôme Waser, Laure Menin, Natalia Gasilova, Nina Declas

Hypervalent iodine reagents have recently emerged as powerful tools for late-stage peptide and protein functionalization. Herein we report a tyrosine bioconjugation methodology for the introduction of hypervalent iodine onto biomolecules under physiologica ...

2022

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

Luc Patiny, Paul Joseph Dyson, Daniel Ortiz Trujillo, Laure Menin

Although genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corre ...

SPRINGER2022

Characterization of the Time-Domain Isotopic Beat Patterns of Monoclonal Antibodies in Fourier Transform Mass Spectrometry

Laure Menin, Natalia Gasilova

The time-domain transients in the Fourier transform mass spectrometry (FTMS) analysis of monoclonal antibodies (mAbs) are known to exhibit characteristic isotopic beat patterns. These patterns are defined by the isotopic distributions of all gaseous mAb io ...

2022

Tyrosine bioconjugation with hypervalent iodine (vol 13, pg 12808, 2022)

Jérôme Waser, Laure Menin, Natalia Gasilova, Nina Declas

Correction for 'Tyrosine bioconjugation with hypervalent iodine' by Nina Declas et al., Chem. Sci., 2022, 13, 12808-12817, https://doi.org/10.1039/D2SC04558C. ...

2022

Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes

Daniel Ortiz Trujillo, Laure Menin, Hikari Ananda Infinity Yoshihara

The circadian clock is a ubiquitous molecular time-keeping mechanism which synchronizes cellular, tissue, and systemic biological functions with 24-hour environmental cycles. Local circadian clocks drive cell type- and tissuespecific rhythms and their dysr ...

2022

Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade

Laure Menin, Natalia Gasilova

Monoclonal antibodies (mAbs) are protein biotherapeutics with a proven efficacy toward fighting life-threatening diseases. Their exceptional healing potential drives the annual increase in the number of novel mAbs and other antibody-like molecules entering ...

SWISS CHEMICAL SOC2022

On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid

Philippe Renaud, Arnaud Bertsch, Hilal Lashuel, Daniel Ortiz Trujillo, Laure Menin, Joan Teixidor, Salvatore Novello

Continuous fluidic sampling systems allow collection of brain biomarkers in vivo. Here, we propose a new sequential and intermittent sampling paradigm using droplets, called Droplet on Demand (DoD). It is implemented in a microfabricated neural probe and a ...

AMER CHEMICAL SOC2022

The pro-apoptotic properties of a phytonutrient rich infusion of A. cherimola leaf extract on AML cells

Laure Menin, Natalia Gasilova, Rita Sarkis, Maria Younes

Annonaceae family has broad uses in herbal medicine for treatment of several diseases, whether through seeds' or leaves' extracts. The present study investigates the antiproliferative and antitumor activity of Annona cherimola aqueous leaf (AAL) extract/in ...

2021

Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept

Luc Patiny, Daniel Ortiz Trujillo, Laure Menin, Francesco Stellacci, Anna Murello, Simone Giaveri, Shiyu Cheng

The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constant ...

Wiley2021

Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry

Yury Tsybin, Laure Menin, Anton Kozhinov, Natalia Gasilova, Konstantin Nagornov

The therapeutic efficacy and pharmacokinetics of antibody-drug conjugates (ADCs) in general, and antibody-oligonucleotide conjugates (AOCs) in particular, depend on the drug-to-antibody ratio (DAR) distribution and average value. The DAR is considered a cr ...

AMER CHEMICAL SOC2021

The methylome of the model arbuscular mycorrhizal fungus, Rhizophagus irregularis, shares characteristics with early diverging fungi and Dikarya

Laure Menin, Natalia Gasilova

Early-diverging fungi (EDF) are distinct from Dikarya and other eukaryotes, exhibiting high N6-methyldeoxyadenine (6mA) contents, rather than 5-methylcytosine (5mC). As plants transitioned to land the EDF sub-phylum, arbuscular mycorrhizal fungi (AMF; Glom ...

NATURE PORTFOLIO2021

Biogeography of microbial bile acid transformations along the murine gut

Rizlan Bernier-Latmani, Laure Menin, Lyne Desharnais, Solenne Anne Marie Marion

Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These tran ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020

Aom(2)S: A new web-based application for DNA/RNA tandem mass spectrometry data interpretation

Luc Patiny, Francisco Sepulveda, Paul Joseph Dyson, Daniel Ortiz Trujillo, Laure Menin, Natalia Gasilova

Rationale The Analysis of Oligonucleotide Modifications from Mass Spectra (Aom(2)S) was created to support the analysis of oligonucleotide mass spectra. This application complements the existing software tools by providing a comprehensive analysis of oligo ...

WILEY2020

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Sandrine Gerber, Luigi Bonacina, Daniel Ortiz Trujillo, Laure Menin, Raphaël Jovita De Matos, Jérémy Vuilleumier

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecu ...

2019