Publications de François Rémi Pierre Noverraz

DNA Encapsulation in Polymeric-Based Nanomaterials for Authentication and Tracking

Sandrine Gerber, François Rémi Pierre Noverraz

Fuel theft poses a significant threat to economic stability, undermining governments revenues and global security while benefiting criminal networks. Combating this issue requires coordinated efforts including innovative technological solutions to secure t ...

American Chemical Society (ACS)2025

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Sandrine Gerber, François Rémi Pierre Noverraz, Alireza Kavand

With its exceptional biocompatibility, alginate emerged as a highly promising biomaterial for a large range of applications in regenerative medicine. Whether in the form of microparticles, injectable hydrogels, rigid scaffolds, or bioinks, alginate provide ...

2024

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the prefe ...

2023

Multicomponent Alginate-Derived Hydrogel Microspheres Presenting Hybrid Ionic-Covalent Network and Drug Eluting Properties

Sandrine Gerber, François Rémi Pierre Noverraz, Luca Szabó

The development of multifunctional encapsulation biomaterials could help the translation of cell‐based therapies into standard medical care. One of the major hurdles in the field of encapsulated cell transplantation is the current lack of materials present ...

Wiley-VHCA AG2020

Cross-Reactive Alginate Derivatives for the Production of Dual Ionic−Covalent Hydrogel Microspheres Presenting Tunable Properties for Cell Microencapsulation

Sandrine Gerber, Aurélien Bornet, François Rémi Pierre Noverraz, Luca Szabó

The production of hydrogel micropsheres (MS) presenting physical, mechanical, and biological properties which can be modulated by their chemical composition is required to enlarge the panel of biomaterials for cell transplantation therapies. Functionalizat ...

2019

Beneficial effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Aurélien Thomas, Luca Szabó

Porcine hepatocytes transplanted during acute liver failure might support metabolic functions until the diseased liver recovers its function. Here, we isolated high numbers of viable pig hepatocytes and evaluated hepatocyte functionality after encapsulatio ...

2018

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Aurélien Thomas, Luca Szabó

LIPPINCOTT WILLIAMS & WILKINS2018

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Sandrine Gerber, Daniel Ortiz Trujillo, Léo Bühler, François Rémi Pierre Noverraz, Luca Szabó

The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well- ...

2018

Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Jutta Christine Wandrey, Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

American Chemical Society2017

Contribution of polymeric materials to progress in xenotransplantation of microencapsulated cells - A review

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

Cell microencapsulation and subsequent transplantation of the microencapsulated cells require multidisciplinary approaches. Physical, chemical, biological, engineering, and medical expertise has to be combined. Several natural and synthetic polymeric mater ...

2016

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Françoise Borcard, Léo Bühler, François Rémi Pierre Noverraz, Virginia Crivelli, Solène Marcelle Françoise Marie Passemard

Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Human mesenchymal stromal cells improve survival and function of pancreatic iislets by cell-to-cell contact through N-cadherin

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

Wiley-Blackwell2015

Human Mesenchymal Stromal Cells Improve Survival And Function Of Pancreatic Iislets By Cell-To-Cell Contact Through N-Cadherin

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

Lippincott Williams & Wilkins2015