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Olivier Pierre Zava

Cette personne n’est plus à l’EPFL

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Publications associées (33)

Anticancer activity of opened arene ruthenium metalla-assemblies

Paul Joseph Dyson, Olivier Pierre Zava

Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)2Ru2(OO.intrsec.OO)2]2 ...

Royal Society of Chemistry2010

Thiophenolato-bridged dinuclear arene ruthenium complexes: a new family of highly cytotoxic anticancer agents

Paul Joseph Dyson, Olivier Pierre Zava

New cationic diruthenium complexes of the type [(arene)2Ru2(SPh)3]+, arene being C6H6, p-iPrC6H4Me, C6Me6, C6H5R, where R = (CH2)nOC(O)C6H4-p-O(CH2)6CH3 or (CH2)nOC(O)CH:CHC6H4-p-OCH3 and n = 2 or 4, are obtained from the reaction of the corresponding prec ...

Royal Society of Chemistry2010

Evidence for Drug Release from a Metalla-Cage Delivery Vector Following Cellular Internalisation

Paul Joseph Dyson, Olivier Pierre Zava

The authors have encapsulated in the cavity of [Ru6(p-iPrC6H4Me)6(tpt)2-(C6H2O4)3]6+ (tpt = 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine), and intrinsically fluorescent pyrenyl compd. (pyrene-R = 1-(4,6-dichloro-1,3,5-trianzin-2-yl)pyrene), thus giving rise to ...

2010

Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage

Paul Joseph Dyson, Anna Katherine Renfrew, Olivier Pierre Zava

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene (p-PriC6H4Me) ruthenium building blocks and 2,5-dioxydo-1,4-benzoquinonato (dobq) bridges, in the presence of a functionalized pyrenyl deriv. (pyrene-R), aff ...

Royal Society of Chemistry2010

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava, elena vergara

Gold(I) complexes bearing water-sol. phosphine ligands, including 1,3,5-triaza-7-phosphaadamantane (PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), and sodium triphenylphosphine trisulfonate (TPPTS), in combination with thionate liga ...

Wiley-Blackwell2010

Synthesis, Characterization and Anticancer Activity of Porphyrin-Containing Organometallic Cubes

Paul Joseph Dyson, Olivier Pierre Zava

Self-assembly of 5,10,15,20-tetra(4-pyridyl)porphyrin (tpp-H2) and 5,10,15,20-tetra(4-pyridyl)porphyrin-M(ii) (M=Ni (tpp-Ni); Zn (tpp-Zn)) tetradentate panels with the dinuclear p-cymene ruthenium clips [Ru2(p-cymene)2(C2O4)Cl2] and [Ru2(p-cymene)2(C6H2O4) ...

CSIRO Publishing2010

Development of Bimetallic Titanocene-Ruthenium-Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties

Philippe Richard, Olivier Pierre Zava, Fabio Edafe

A series of bimetallic titanium-ruthenium complexes of general formula (η5-C5H5)(μ-η5:κ1-C5H4(CR12)nPR2R3)TiCl2RuCl2 (n = 0, 1, 2 or 4; R1 = H or Me; R2 = H, Ph, or Cy; R3 = Ph or Cy) have been synthesized, including two novel compds. as wel ...

American Chemical Society2010

Antiproliferative Activity of Gold(I) Alkyne Complexes Containing Water-Soluble Phosphane Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava, elena vergara

A series of mono-, di-, and trinuclear organometallic alkynyl phosphane gold(I) complexes contg. the stable and water-sol. PTA and DAPTA ligands have been synthesized and characterized. The solid-state structure of one of these compds. was also established ...

American Chemical Society2010

Rational Design of Highly Cytotoxic η6-Arene β-Diketiminato-Ruthenium Complexes

Rosario Scopelliti, Paul Joseph Dyson, Andrew Douglas Phillips, Alexey Nazarov, Olivier Pierre Zava

A series of ruthenium-benzene complexes with β-diketiminate ligands modified with electron-withdrawing groups were prepd. and characterized by NMR spectroscopy, mass spectrometry, and single-crystal x-ray diffraction. The complexes are stable in air and un ...

American Chemical Society2010

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Paul Joseph Dyson, Olivier Pierre Zava

The reaction of copper(II) chloride or copper(II) acetate with 6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo-[3,2-d][1]benzazepine (HL1), 9-bromo-6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine (HL2), N-9-bromo-7,12 ...

2010

Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava

The reaction of the five- or six-membered C,N or C,S-palladacycles [(L)PdCl]2 with PTA (1,3,5-triaza-7-phosphaadamantane) led to the monomeric complexes [(L)Pd(PTA)Cl] 6a, 6b and 7 where LH= N,N-dimethyl-1-phenylmethanamine, benzyl(methyl)sulfane or 1-meth ...

Royal Society of Chemistry2009

A cytotoxic ruthenium tris(bipyridyl) complex that accumulates at plasma membranes

Michael Graetzel, Horst Vogel, Shaik Mohammed Zakeeruddin, Paul Joseph Dyson, Christophe Danelon, Olivier Pierre Zava

Wiley-Blackwell2009

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Michael Groessl, Olivier Pierre Zava, Muhammad Hanif, Frédéric Schmitt

The synthesis and in vitro anticancer activity of dihalo(η6-p-cymene)(3,5,6-bicyclophosphite-α-D-glucofuranoside)ruthenium(II) complexes are described. The compds. were characterized by NMR spectroscopy and ESI mass spectrometry, and the mol. structures of ...

2008

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