Publications de Noémie Matthey

Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species

Noémie Matthey, Melanie Blokesch, Esther Jeanne Collas, Candice Stoudmann, Lisa Christina Metzger

Bacteria of the genus Vibrio are common members of aquatic environments where they compete with other prokaryotes and defend themselves against grazing predators. A macromolecular protein complex called the type VI secretion system (T6SS) is used for both ...

2019

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

Christian Iseli, Nicolas Jean Philippe Guex, Noémie Matthey, Melanie Blokesch, Candice Stoudmann, Sandrine Stutzmann

Natural competence for transformation is a primary mode of horizontal gene transfer. Competent bacteria are able to absorb free DNA from their surroundings and exchange this DNA against pieces of their own genome when sufficiently homologous. However, the ...

2019

Common concepts for bacterial collectives

Noémie Matthey

2019

Two nanomachines drive evolution in diverse Vibrio species

Noémie Matthey

Horizontal gene transfer (HGT) has a major impact on bacterial evolution, leading to acquisition or deletion of genes and gene clusters, including those encoding antibiotic resistances and virulence factors. HGT therefore contributes to pathogen emergence, ...

EPFL2019

Long-Read-Based Genome Sequences of Pandemic and Environmental Vibrio cholerae Strains

Noémie Matthey, Melanie Blokesch, Natalia Carolina Drebes Dorr

The bacterium Vibrio cholerae exhibits two distinct lifestyles, one as an aquatic bacterium and the other as the etiological agent of the pandemic human disease cholera. Here, we report closed genome sequences of two seventh pandemic V. cholerae O1 El Tor ...

2018

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY

Noémie Matthey, Melanie Blokesch, Sandrine Stutzmann, Charles Ulric V Van der Henst, Tiziana Scrignari, Lisa Christina Metzger

Type VI secretion systems (T6SSs) are nanomachines used for interbacterial killing and intoxication of eukaryotes. Although Vibrio cholerae is a model organism for structural studies on T6SSs, the underlying regulatory network is less understood. A recent ...

Elsevier2016

The DNA-Uptake Process of Naturally Competent Vibrio cholerae

Noémie Matthey, Melanie Blokesch

The sophisticated DNA-uptake machinery used during natural transformation is still poorly characterized, especially in Gram-negative bacteria where the transforming DNA has to cross two membranes as well as the peptidoglycan layer before entering into the ...

Elsevier2016