Publications de Fabien Ferrage

Nuclear overhauser spectroscopy of chiral CHD methylene groups

Nuclear magnetic resonance spectroscopy (NMR) can provide a great deal of information about structure and dynamics of biomolecules. The quality of an NMR structure strongly depends on the number of experimental observables and on their accurate conversion ...

Springer Verlag2016

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation

Geoffrey Bodenhausen, Fabien Ferrage, Nicola Salvi

Intrinsically disordered proteins and intrinsically disordered regions (IDRs) are ubiquitous in the eukaryotic proteome. The description and understanding of their conformational properties require the development of new experimental, computational, and th ...

Elsevier2015

Cross-correlated relaxation measurements under adiabatic sweeps: determination of local order in proteins

Geoffrey Bodenhausen, Fabien Ferrage, Nicola Salvi, Pavel Kaderavek

Adiabatically swept pulses were originally designed for the purpose of broadband spin inversion. Later, unexpected advantages of their utilization were also found in other applications, such as refocusing to excite spin echoes, studies of chemical exchange ...

Springer Verlag2015

Nanosecond Time Scale Motions in Proteins Revealed by High-Resolution NMR Relaxometry

Geoffrey Bodenhausen, Fabien Ferrage

Understanding the molecular determinants underlying protein function requires the characterization of both structure and dynamics at atomic resolution. Nuclear relaxation rates allow a precise characterization of protein dynamics at the Larmor frequencies ...

American Chemical Society2013

Time Scales of Slow Motions in Ubiquitin Explored by Heteronuclear Double Resonance

Geoffrey Bodenhausen, Simone Ulzega, Fabien Ferrage, Nicola Salvi

Understanding how proteins function at the atomic level relies in part on a detailed characterization of their dynamics. Ubiquitin, a small single-domain protein, displays rich dynamic properties over a wide range of time scales. In particular, several reg ...

2012

Preservation of heteronuclear multiple-quantum coherences in NMR by double-resonance irradiation

Geoffrey Bodenhausen, Mariachiara Verde, Simone Ulzega, Fabien Ferrage

A heteronuclear double-resonance (HDR) method based on MLEV-32 or WALTZ-32 pulse sequences has been designed for the investigation of relaxation of heteronuclear multiple-quantum (MQ) coherences. The theoretical analysis of this technique uses average Hami ...

2009

Heteronuclear Double Resonance in NMR Spectroscopy: Relaxation of Multiple Quantum Coherences

Geoffrey Bodenhausen, Mariachiara Verde, Simone Ulzega, Fabien Ferrage

Theoretical and experimental investigations of the relaxation rates of multiple-quantum coherences during heteronuclear double resonance (HDR) pulse sequences are presented. Average Liouvillian theory yields analytical expressions to describe the effective ...

2009

Multiple-Timescale Dynamics of Side-Chain Carboxyl and Carbonyl Groups in Proteins by C-13 Nuclear Spin Relaxation

Geoffrey Bodenhausen, Mikael Akke, Fabien Ferrage

Side-chain carboxyl and carbonyl groups play a major role in protein interactions and enzyme catalysis. A series of C-13 relaxation experiments is introduced to study the dynamics of carboxyl and carbonyl groups in protein side chains on both fast (sub-ns) ...

American Chemical Society2008

Single or triple gradients?

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Fabien Ferrage

Pulsed Field Gradients (PFGs) have become ubiquitous tools not only for Magnetic Resonance Imaging (MRI), but also for NMR experiments designed to study translational diffusion, for spatial encoding in ultra-fast spectroscopy, for the selection of desirabl ...

Academic Press Inc - Elsevier Science2008

Accurate Measurement of Longitudinal Cross-Relaxation Rates in Nuclear Magnetic Resonance

Geoffrey Bodenhausen, Fabien Ferrage

2007

Protein Backbone Dynamics through 13C’ - 13Cα Cross-Relaxation in NMR Spectoscopy

Geoffrey Bodenhausen, Fabien Ferrage

2006