Publications de Esra Güç | EPFL Graph Search

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Melody Swartz, Alexandre de Titta, Witold Waldemar Kilarski, Sachiko Hirosue, Marcela Rincón-Restrepo, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Nature Research2020

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Ioanna Keklikoglou, Esra Güç, Michele De Palma, Mario Leonardo Squadrito, Antonino Cassarà, Chiara Cianciaruso, Alan Nicolas Thierry Guichard

Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can ...

2019

Characterization of a B16-F10 melanoma model locally implanted into the ear pinnae of C57BL/6 mice

Witold Waldemar Kilarski, Esra Güç

The common experimental use of B16-F10 melanoma cells focuses on exploring their metastatic potential following intravenous injection into mice. In this study, B16-F10 cells are used to develop a primary tumor model by implanting them directly into the ear ...

2018

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Melody Swartz, Witold Waldemar Kilarski, Esra Güç, Marco Pisano, Valentina Triacca

Rationale: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across ...

Lippincott Williams & Wilkins2017

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Esra Güç, Manuel Andreas Fankhauser

Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...

2017

Perivascular Macrophages Limit Permeability

Melody Swartz, Witold Waldemar Kilarski, Esra Güç, Michele De Palma, Mario Leonardo Squadrito

Objective-Perivascular cells, including pericytes, macrophages, smooth muscle cells, and other specialized cell types, like podocytes, participate in various aspects of vascular function. However, aside from the well-established roles of smooth muscle cell ...

American Heart Association2016

Engineering Interactions between Growth Factors and the Extracellular Matrix

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Esra Güç

Federation Amer Soc Exp Biol2015

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Stéphanie Elisabeth Metzger, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Jeffrey James Rice, Esra Güç, Federico Tortelli

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

American Association for the Advancement of Science2014

Engineering lymphangiogenesis : methods, characterization and functional consequences

Esra Güç

EPFL2014

Engineered fibrin-binding VEGF-C variant promotes lymphangiogenesis in vitro and in vivo in a dermal wound healing model

Jeffrey Alan Hubbell, Melody Swartz, Miriella Carmela Pasquier, Witold Waldemar Kilarski, Esra Güç

2009