Publications de Guillaume Poirier

Early life adoption shows rearing environment supersedes transgenerational effects of paternal stress on aggressive temperament in the offspring

Maria del Carmen Sandi Perez, Guillaume Poirier, Olivia Zanoletti, Sonakshi Gupta

Prenatal experience and transgenerational influences are increasingly recognized as critical for defining the socio-emotional system, through the development of social competences and of their underlying neural circuitries. Here, we used an established rat ...

2021

Emergence in extinction of enhanced and persistent responding to ambiguous aversive cues is associated with high MAOA activity in the prelimbic cortex

Maria del Carmen Sandi Perez, Guillaume Poirier

There is a great deal of individual variability in the emotional outcomes of potentially traumatic events, and the underlying mechanisms are only beginning to be understood. In order to further our understanding of individual trajectories to trauma, its vu ...

2016

Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Nathalie Just, Guillaume Poirier

Early-life stress and biological predispositions are linked to mood and personality disorders related to aggressive behavior. We previously showed that exposure to peripubertal stress leads to increased anxiety-like behaviors and aggression against males a ...

2016

Impaired spatial working memory after anterior thalamic lesions: recovery with cerebrolysin and enrichment

Guillaume Poirier

Lesions to the anterior thalamic nuclei (ATN) in rats produce robust spatial memory deficits that reflect their influence as part of an extended hippocampal system. Recovery of spatial working memory after ATN lesions was examined using a 30-day administra ...

Springer Heidelberg2016

The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions

Maria del Carmen Sandi Perez, Damien Sébastien Huzard, Guillaume Poirier, Michael van der Kooij

Properties of the environment play an important role in animal wellbeing and may modulate the effects of external threats. Whereas stressors can affect emotion and impair cognition, environmental enrichment may prevent the occurrence of such negative seque ...

Pergamon-Elsevier Science Ltd2015

Social deficits induced by peripubertal stress in rats are reversed by resveratrol

Maria del Carmen Sandi Perez, Guillaume Poirier, Olivia Zanoletti

Adolescence is increasingly recognized as a critical period for the development of the social system, through the maturation of social competences and of their underlying neural circuitries. The present study sought to test the utility of resveratrol, a di ...

2014

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Pierre Magistretti, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Didier Trono, Anna Claire Groner, Cristina Marquez Vega, Guillaume Poirier

Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...

Nature Publishing Group2013

Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Guillaume Poirier

Exposure to violence is traumatic and an important source of mental health disturbance, yet the factors associated with victimization remain incompletely understood. The aim of the present study was to investigate factors related to vulnerability to depres ...

Frontiers Research Foundation2013

Evidence for biological roots in the transgenerational transmission of intimate partner violence

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Xavier Fontana, Basira Salehi, Cristina Marquez Vega, Vandana Veenit, Guillaume Poirier

Intimate partner violence is a ubiquitous and devastating phenomenon for which effective interventions and a clear etiological understanding are still lacking. A major risk factor for violence perpetration is childhood exposure to violence, prompting the p ...

2012

EARLY-ONSET DYSFUNCTION OF RETROSPLENIAL CORTEX PRECEDES OVERT AMYLOID PLAQUE FORMATION IN Tg2576 MICE

Guillaume Poirier

A mouse model of amyloid pathology was used to first examine using a cross sectional design changes in retrosplenial cortex activity in transgenic mice aged 5, 11, 17, and 23 months. Attention focused on: (1) overt amyloid labeled with beta-amyloid((1-42)) ...

2011

Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Jorge Eduardo Castro Cifuentes, Cristina Marquez Vega, Guillaume Poirier

The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention. The basolateral complex of the amygdala (B ...

Public Library of Science2010

Post-Surgical Interval And Lesion Location Within The Limbic Thalamus Determine Extent Of Retrosplenial Cortex Immediate-Early Gene Hypoactivity

Guillaume Poirier

Four experiments examined the disruptive effects of selective lesions in limbic thalamic nuclei on retrosplenial cortex function, as characterized by striking changes in immediate-early gene activity. Major goals were to test the specificity of these retro ...

2009