Publications de Nishanth Ulhas Nair

A maximum-likelihood approach for building cell-type trees by lifting

Philipp Bucher, Bernard Moret, Yu Lin, Nishanth Ulhas Nair, Mingfu Shao, Paulina Grnarova, Laura Madeleine Hunter

Background: In cell differentiation, a less specialized cell differentiates into a more specialized one, even though all cells in one organism have (almost) the same genome. Epigenetic factors such as histone modifications are known to play a significant r ...

2016

Study of cell differentiation by phylogenetic analysis using histone modification data

Philipp Bucher, Bernard Moret, Yu Lin, Nishanth Ulhas Nair, Paulina Grnarova, Jelena Antic, Ana Manasovska

Background: In cell differentiation, a cell of a less specialized type becomes one of a more specialized type, even though all cells have the same genome. Transcription factors and epigenetic marks like histone modifications can play a significant role in ...

BioMed Central2014

Probabilistic partitioning methods to find significant patterns in ChIP-Seq data

Philipp Bucher, Bernard Moret, Nishanth Ulhas Nair, Sunil Kumar

Motivation: We have witnessed an enormous increase in ChIP-Seq data for histone modifications in the past few years. Discovering significant patterns in these data is an important problem for understanding biological mechanisms. Results: We propose probabi ...

Oxford University Press2014

Computational studies in epigenomics using histone modification data

Nishanth Ulhas Nair

Epigenetic factors like histone modifications are known to play an important role in gene regulation and cell differentiation. Recently, thanks to advances in technologies like ChIP-Seq which is a high-throughput, high resolution, and low cost technology ...

EPFL2014

Phylogenetic Analysis of Cell Types Using Histone Modifications

Philipp Bucher, Bernard Moret, Yu Lin, Nishanth Ulhas Nair

Springer Verlag2013

Genome-Wide Evaluation of Histone Methylation Changes Associated with Leaf Senescence in Arabidopsis

Nishanth Ulhas Nair

Leaf senescence is the orderly dismantling of older tissue that allows recycling of nutrients to developing portions of the plant and is accompanied by major changes in gene expression. Histone modifications correlate to levels of gene expression, and this ...

Public Library of Science2012

ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries

Philipp Bucher, Bernard Moret, Nishanth Ulhas Nair

The advent of high-throughput technologies such as ChIP-seq has made possible the study of histone modifications. A problem of particular interest is the identification of regions of the genome where different cell types from the same organism exhibit diff ...

Public Library of Science2012