Publications de Azadeh Khoushabi

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser, Céline Samira Wyss, Martin Broome, Peyman Karami

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Dominique Pioletti, Pierre-Etienne Bourban, Azadeh Khoushabi, Céline Samira Wyss, Baris Çaglar

One of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacryl ...

2018

A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single imp ...

Elsevier2016

In-situ photopolymerized and monitored implants: successful application to an intervertebral disc replacement

Dominique Pioletti, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerization is a common method to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler by using ultra-violet light. Traditionally, photopolymerization has bee ...

Spie-Int Soc Optical Engineering2016

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Miniature probe for the delivery and monitoring of a photopolymerizable material

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerization is a common method to cure materials initially in a liquid state, such as dental implants or bone or tissue fillers. Recent advances in the development of biocompatible gel- and cement-systems open up an avenue for in situ photopolymeri ...

SPIE Society of Photo-optical Instrumentation Engineers2015

Photo-polymerization, swelling and mechanical properties of cellulose fibre reinforced poly(ethylene glycol) hydrogels

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi

The application of hydrogels as load-bearing biomedical components is often limited by their mechanical properties. Often an attempt to improve a hydrogel's stiffness is accompanied by a loss of toughness and swelling properties. In this work, we show that ...

Elsevier Sci Ltd2015

Development of an in situ controllable polymerization tool and process for hydrogel used to replace nucleus pulposus

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Currently implants or tissue replacements are inserted either as a whole implant or by injecting a liquid which polymerizes to form a solid implant at the appropriate location. This is either highly invasive or not controllable. We developed a tool to perf ...

Spie-Int Soc Optical Engineering2015

Photopolymerization device for minimally invasive implants: application to nucleus pulposus replacement

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerization is a common tool to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler. Traditionally, photopolymerization has been used mainly in dentistry. Ov ...

Springer2015

In-situ photopolymerization and monitoring device for controlled shaping of tissue fillers, replacements or implants

Dominique Pioletti, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerization is a common tool to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler simply by illumination. Traditionally, photopolymerization has been used ...

Spie-Int Soc Optical Engineering2015

Minimally Invasive Photopolymerization In Intervertebral Disc Tissue Cavities

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerized hydrogels are commonly used for a broad range of biomedical applications. As long as the polymer volume is accessible, gels can easily be hardened using light illumination. However, in clinics, especially for minimally invasive surgery, it ...

Spie-Int Soc Optical Engineering2014

Multi-Scale Modeling Of Photopolymerization For Medical Hydrogel-Implant Design

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Salma Farahi

We report on the modeling of a photopolymerizable hydrogel and its application as a replacement of the interior of the intervertebral disc (so called Nucleus Pulposus). The hydrogel is initially injected in its liquid form and then photopolymerized via a s ...

Spie-Int Soc Optical Engineering2013

Mechanical Properties Of A Photopolymerizable Hydrogel For Intervertebral Disc Replacement

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi

We report on the modelling and experimental validation of a photopolymerizable hydrogel for a Nucleus Pulposus replacement. ...

De Gruyter2013