Publications de Lorenzo Righetto

Detection of Vibrio cholerae O1 and O139 in environmental waters of rural Bangladesh: a flow-cytometry-based field trial

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

Presence of Vibrio cholerae serogroups O1 and O139 in the waters of the rural area of Matlab, Bangladesh, was investigated with quantitative measurements performed with a portable flow cytometer. The relevance of this work relates to the testing of a field ...

Cambridge University Press2015

Hydrological, Anthropogenic and Ecological Processes in Cholera Dynamics

Lorenzo Righetto

The present Thesis deals with understanding, measuring and modelling epidemic cholera. The relevance of the endeavour stems from the fact that mathematical epidemiology, properly guided by model-guided field validation, is a reliable and powerful tool to m ...

EPFL2013

Spatially Explicit Conditions for Waterborne Pathogen Invasion

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

Waterborne pathogens cause many possibly lethal human diseases. We derive the condition for pathogen invasion and subsequent disease outbreak in a territory with specific, space-inhomogeneous characteristics (hydrological, ecological, demographic, and epid ...

Univ Chicago Press2013

Rainfall mediations in the spreading of epidemic cholera

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

Following the empirical evidence of a clear correlation between rainfall events and cholera resurgence that was observed in particular during the recent outbreak in Haiti, a spatially explicit model of epidemic cholera is re-examined. Specifically, we test ...

Elsevier Sci Ltd2013

Modelling cholera epidemics: the role of waterways, human mobility and sanitation

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

We investigate the role of human mobility as a driver for long-range spreading of cholera infections, which primarily propagate through hydrologically controlled ecological corridors. Our aim is to build a spatially explicit model of a disease epidemic, wh ...

2012

Hydroclimatology of dual-peak annual cholera incidence: Insights from a spatially explicit model

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

Cholera incidence in some regions of the Indian subcontinent may exhibit two annual peaks although the main environmental drivers that have been linked to the disease (e.g., sea surface temperature, zooplankton abundance, river discharge) peak once per yea ...

2012

Reassessment of the 2010-2011 Haiti cholera outbreak and rainfall-driven multiseason projections

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Melanie Blokesch, Lorenzo Mari, Marino Gatto

Mathematical models can provide key insights into the course of an ongoing epidemic, potentially aiding real-time emergency management in allocating health care resources and by anticipating the impact of alternative interventions. We study the ex post rel ...

2012

The role of aquatic reservoir fluctuations in long-term cholera patterns

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

We propose and analyze an important extension of standard cholera epidemiological models, explicitly accounting for fluctuations of water availability to the human community under study. The seasonality of water input in the reservoir drives the variation ...

2012

Generalized reproduction numbers and the prediction of patterns in waterborne disease

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

Understanding, predicting, and controlling outbreaks of waterborne diseases are crucial goals of public health policies, but pose challenging problems because infection patterns are influenced by spatial structure and temporal asynchrony. Although explicit ...

Natl Acad Sciences2012

On the role of human mobility in the spread of cholera epidemics: towards an epidemiological movement ecology

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Lorenzo Mari, Marino Gatto

We investigate the role of human mobility as a driver for long-range spreading of cholera infections, which otherwise primarily propagate through hydrologically controlled ecological corridors. We rely on a recent mechanistic, field-data validated, spatial ...

Wiley-Blackwell2012

A transmission model of the 2010 cholera epidemic in haiti

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Melanie Blokesch, Lorenzo Mari, Marino Gatto

2011

Prediction of the spatial evolution and effects of control measures for the unfolding Haiti cholera outbreak

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Melanie Blokesch, Lorenzo Mari, Marino Gatto

Here we propose spatially explicit predictions of the residual progression of the current Haiti cholera outbreak accounting for the dynamics of susceptible and infected individuals within different local human communities, and for the redistribution among ...

American Geophysical Union2011

Modelling human movement in cholera spreading along fluvial systems

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Righetto, Marino Gatto

We propose an important extension of a previously studied, spatially explicit and hydrology-driven, model of cholera spreading. Our reformulation concerns the role of different modelizations of human movement on the overall dynamics of the epidemics, which ...

2011