Publications de Lely Feletti | EPFL Graph Search

Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

Aleksandra Radenovic, Hilal Lashuel, Lely Feletti, Khalid Ashraf Mohie Ibrahim

The process of protein aggregation, central to neurodegenerative diseases like Huntington’s, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in disease ...

Springer Science and Business Media LLC2025

Controlled Sensing of User-Defined Aptamer-Based Targets Using Scanning Ionic Conductance Spectroscopy

Aleksandra Radenovic, Lely Feletti, Georg Fantner, Barney Frederick Drake, Marcos Penedo Garcia, Helena Miljkovic, Wayne Yang Wen Wei, Zahra Ayar Dulabi

Solid-state nanopores offer the possibility of detecting disease biomarkers in early diagnostic applications. Standard approaches harness fingerprinting, where protein targets are bound to DNA carriers and detected in free translocation with a solid-state ...

2025

Investigating Focal Adhesion Substructures by Localization Microscopy

Daniel Sage, Aleksandra Radenovic, Lely Feletti, Hendrik Georges Deschout

Cells rely on focal adhesions (FAs) to carry out a variety of important tasks, including motion, environmental sensing, and adhesion to the extracellular matrix. Although attaining a fundamental characterization of FAs is a compelling goal, their extensive ...

Elsevier2017

Combining PALM and SOFI for quantitative imaging of focal adhesions in living cells

Theo Lasser, Aleksandra Radenovic, Lely Feletti, Azat Sharipov, Hendrik Georges Deschout, Tomas Lukes

Focal adhesions are complicated assemblies of hundreds of proteins that allow cells to sense their extracellular matrix and adhere to it. Although most focal adhesion proteins have been identified, their spatial organization in living cells remains challen ...

Spie-Int Soc Optical Engineering2017

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

Marcel Leutenegger, Theo Lasser, Aleksandra Radenovic, Lely Feletti, Daniel Pawel Szlag, Azat Sharipov, Hendrik Georges Deschout, Tomas Lukes

Live-cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenge for super-resolution microscopy. Here we address this important issue by combining photoactivated localization microscopy (PALM) with super-res ...

Nature Publishing Group2016

High-Resolution Correlative Microscopy: Bridging the Gap between Single Molecule Localization Microscopy and Atomic Force Microscopy

Aleksandra Radenovic, Lely Feletti, Georg Fantner, Pascal Damian Odermatt, Arun Shivanandan, Hendrik Georges Deschout, Adrian Pascal Nievergelt, Radek Jankele

Nanoscale characterization of living samples has become essential for modern biology. Atomic force microscopy (AFM) creates topological images of fragile biological structures from biomolecules to living cells in aqueous environments. However, correlating ...

American Chemical Society (ACS)2015

Probing the size of proteins with glass nanopores

Aleksandra Radenovic, Lely Feletti, Melanie Blokesch, Lorenz Jan Steinbock, Roman Bulushev, Swati Krishnan

Single molecule studies using nanopores have gained attention due to the ability to sense single molecules in aqueous solution without the need to label them. In this study, short DNA molecules and proteins were detected with glass nanopores, whose sensiti ...

Royal Soc Chemistry2014