Publications de Florence Armand

Conditional essentiality of the 11-subunit complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium hafniense strain DCB-2

Christof Holliger, Julien Maillard, Florence Armand, Romain Hamelin, Mathilde Stéphanie Willemin

In oxidative phosphorylation, respiratory complex I serves as an entry point in the electron transport chain for electrons generated in catabolic processes in the form of NADH. An ancestral version of the complex, lacking the NADH-oxidising module, is enco ...

Frontiers Media SA2024

Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor

Gerardo Turcatti, Benjamin Rappaz, Florence Armand, Romain Hamelin

The process of protein phosphorylation is involved in numerous cell functions. In particular, phosphotyrosine (pY) has been reported to play a role in red blood cell (RBC) functions, including the cytoskeleton organization. During their storage before tran ...

2023

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Freddy Radtke, Nadine Fournier, Florence Armand, Romain Hamelin, Linlin Cao, Maria Pavlou

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitati ...

2023

Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms

Christof Holliger, Julien Maillard, Florence Armand, Romain Hamelin, Mathilde Stéphanie Willemin

IntroductionDesulfitobacterium hafniense was isolated for its ability to use organohalogens as terminal electron acceptors via organohalide respiration (OHR). In contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly versatile energy meta ...

Frontiers Media SA2023

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

Florence Armand, Romain Hamelin

The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conform ...

SPRINGERNATURE2022

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

Florence Armand, Nicola Harris, Romain Hamelin, Kathleen Shah, Mati André Marie Moyat

The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina propria along the length of the intesti ...

CELL PRESS2022

Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine

Diego Chiappe, Florence Armand, Romain Hamelin

Human fetal progenitor tenocytes (hFPT) produced in defined cell bank systems have recently been characterized and qualified as potential therapeutic cell sources in tendon regenerative medicine. In view of further developing the manufacture processes of s ...

MDPI2021

Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation

Marc Moniatte, Diego Chiappe, Viesturs Simanis, Andrea Krapp, Elena Cano, Florence Armand, Romain Hamelin, Lucien Fabrice Krapp

Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the rela ...

2019

Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway Genes in Cells of the Monocyte Lineage

Paul Joseph Dyson, Florence Armand, Romain Hamelin, Gianni Sava, Isabelle Mireille Claude Schepens

Lysozyme is one of the most important anti-bacterial effectors in the innate immune system of animals. Besides its direct antibacterial enzymatic activity, lysozyme displays other biological properties, pointing toward a significant anti-inflammatory effec ...

2019

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA

Marc Moniatte, Florence Armand, Romain Hamelin

Plasmodium falciparum is the main cause of disease and death from malaria. P. falciparum virulence resides in the ability of infected erythrocytes (IEs) to sequester in various tissues through the interaction between members of the polymorphic P. falciparu ...

2019

Phosphorylation Of The Var2Csa Extracellular Region Is Associated With Enhanced Adhesive Properties To The Placental Receptor Csa

Marc Moniatte, Florence Armand, Romain Hamelin, Zeineb Fourati

AMER SOC TROP MED & HYGIENE2019

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis

Pierre Gönczy, Coralie Busso, Virginie Hamel, Florence Armand, Isabelle Fluckiger, Romain Hamelin, Paul Guichard

Centrioles are evolutionarily conserved macromolecular structures that are fundamental to form cilia, flagella, and centrosomes. Centrioles are 9-fold symmetrical microtubule-based cylindrical barrels comprising three regions that can be clearly distinguis ...

2017

Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1

Marc Moniatte, Florence Armand, Romain Hamelin

Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology. Plasmodium falciparum encodes a single CK1 isoform, PfCK1, that is expressed at all stages of the parasite's life cycle. We have p ...

Public Library of Science2015

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

Marc Moniatte, Diego Chiappe, John McKinney, Tarun Chopra, Florence Armand, Romain Hamelin

Mycobacterium tuberculosis has a remarkable ability to persist within the human host as a clinically inapparent or chronically active infection. Fatty acids are thought to be an important carbon source used by the bacteria during long term infection. Catab ...

Amer Soc Biochemistry Molecular Biology Inc2014

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Joachim Lingner, Marc Moniatte, Diego Chiappe, Larissa Grolimund, Florence Armand, Romain Hamelin, Eric Aeby

Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified ...

Nature Publishing Group2013

Inactivation of human adenovirus by UV and singlet oxygen as examined by quantitative protein mass spectrometry

Tamar Kohn, Florence Armand, Romain Hamelin, Franziska Sara Bosshard

Amer Chemical Soc2013

Mechanisms of Human Adenovirus Inactivation by Sunlight and UVC Light as Examined by Quantitative PCR and Quantitative Proteomics

Tamar Kohn, Florence Armand, Romain Hamelin, Franziska Sara Bosshard

Human adenoviruses (HAdV) are important pathogens in both industrialized and developing nations. HAdV has been shown to be relatively resistant to monochromatic UVC. Polychromatic UVC, in contrast, is a more effective means of disinfection, presumably due ...

American Society for Microbiology2013

Rapid and selective surveillance of Arabidopsis thaliana genome annotations with Centrifuge

Philipp Bucher, Florence Armand

Centrifuge is a user-friendly system to simultaneously access Arabidopsis gene annotations and intra- and inter-organism sequence comparison data. The tool allows rapid retrieval of user-selected data for each annotated Arabidopsis gene providing, in any c ...

Oxford University Press2005