Publications de Alessandro Daducci

Tractography passes the test: Results from the diffusion-simulated connectivity (disco) challenge

Jean-Philippe Thiran, Alessandro Daducci, Ying-Chia Lin, Sara Sedlar, Caio Seguin, Gabriel Girard, Erick Jorge Canales Rodriguez, Alonso Ramirez Manzanares, Marco Pizzolato, Juan Luis Villarreal Haro, Kenji Marshall, Yang Ji

Estimating structural connectivity from diffusion-weighted magnetic resonance imaging is a challenging task, partly due to the presence of false-positive connections and the misestimation of connection weights. Building on previous efforts, the MICCAI-CDMR ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Jean-Philippe Thiran, Tobias Kober, Elda Fischi Gomez, Alessandro Daducci, Tom Hilbert, Elena Beanato, Gabriel Girard, Julia Brügger, Gian Franco Piredda, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Erick Jorge Canales Rodriguez, Marco Pizzolato, Andéol Geoffroy Cadic-Melchior, Thomas Yu, Chang-Hyun Park

Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...

2022

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Jean-Philippe Thiran, Nicolas Kunz, Tobias Kober, Alessandro Daducci, Tom Hilbert, Gian Franco Piredda, Erick Jorge Canales Rodriguez, Marco Pizzolato, Thomas Yu

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

2021

Hierarchical Microstructure Informed Tractography

Alessandro Daducci, Gabriel Girard, Maxime Descoteaux

Background: Tractography uses diffusion magnetic resonance imaging to noninvasively infer the macroscopic pathways of white matter fibers and it is the only available technique to probe in vivo the structural connectivity of the brain. However, despite thi ...

MARY ANN LIEBERT, INC2021

Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts

Jean-Philippe Thiran, Giorgio Innocenti, David Paul Roger Romascano, Cristina Granziera, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard, Maxime Descoteaux

In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However ...

2021

Resolving bundle-specific intra-axonal T2 values within a voxel using diffusion-relaxation tract-based estimation

Jean-Philippe Thiran, Cristina Granziera, Alessandro Daducci, Muhamed Barakovic, Erick Jorge Canales Rodriguez

At the typical spatial resolution of MRI in the human brain, approximately 60–90% of voxels contain multiple fiber populations. Quantifying microstructural properties of distinct fiber populations within a voxel is therefore challenging but necessary. Whil ...

2020

A new method for accurate in vivo mapping of human brain connections using microstructural and anatomical information

Jean-Philippe Thiran, Alessandro Daducci, Muhamed Barakovic, Maxime Descoteaux

Diffusion magnetic resonance imaging is a noninvasive imaging modality that has been extensively used in the literature to study the neuronal architecture of the brain in a wide range of neurological conditions using tractography. However, recent studies h ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Fast and high-resolution myelin water imaging: Accelerating multi-echo GRASE with CAIPIRINHA

Jean-Philippe Thiran, Reto Meuli, Tobias Kober, Alessandro Daducci, Tom Hilbert, Gian Franco Piredda, Erick Jorge Canales Rodriguez, Marco Pizzolato

Purpose Although several MRI methods have been explored to achievein vivomyelin quantification, imaging the whole brain in clinically acceptable times and sufficiently high resolution remains challenging. To address this problem, this work investigates the ...

Wiley2021

ActiveAx(ADD): Toward non-parametric and orientationally invariant axon diameter distribution mapping using PGSE

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Jonathan Rafael Patino Lopez, Tim Bjørn Dyrby

Purpose Non-invasive axon diameter distribution (ADD) mapping using diffusion MRI is an ill-posed problem. Current ADD mapping methods require knowledge of axon orientation before performing the acquisition. Instead, ActiveAx uses a 3D sampling scheme to e ...

Wiley2020

Tractostorm: The what, why, and how of tractography dissection reproducibility

David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard, Maxime Descoteaux

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called "virtual dissection." Human errors and personal decisions make these manual segmentations har ...

Wiley2020

Topological principles and developmental algorithms might refine diffusion tractography

Jean-Philippe Thiran, Giorgio Innocenti, Alessandro Daducci, Gabriel Girard, Maxime Descoteaux, Tim Bjørn Dyrby

The identification and reconstruction of axonal pathways in the living brain or “ex-vivo” is promising a revolution in connectivity studies bridging the gap from animal to human neuroanatomy with extensions to brain structural–functional correlates. Unfort ...

2019

Advances in computational and statistical diffusion MRI

Alessandro Daducci

Computational methods are crucial for the analysis of diffusion magnetic resonance imaging (MRI) of the brain. Computational diffusion MRI can provide rich information at many size scales, including local microstructure measures such as diffusion anisotrop ...

2019

Sparse wars: A survey and comparative study of spherical deconvolution algorithms for diffusion MRI

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard, Gaëtan Olivier D Rensonnet, Jonathan Rafael Patino Lopez, Erick Jorge Canales Rodriguez, Marco Pizzolato

Spherical deconvolution methods are widely used to estimate the brain's white-matter fiber orientations from diffusion MRI data. In this study, eight spherical deconvolution algorithms were implemented and evaluated. These included two model selection tech ...

2019

Improving Graph-Based Tractography Plausibility Using Microstructure Information

Jean-Philippe Thiran, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard

2019

Deep learning analysis applied to multi-parametric advanced MRI shows higher myelin content and neurite density in juxtacortical lesions compared to periventricular lesions

Meritxell Bach Cuadra, Cristina Granziera, Alessandro Daducci, Po-Jui Lu, Francesco La Rosa, Yi Wang

SAGE PUBLICATIONS LTD2019

A Novel Spatial-Angular Domain Regularisation Approach for Restoration of Diffusion MRI

Jean-Philippe Thiran, Meritxell Bach Cuadra, Alessandro Daducci, Alessandro Mella

In this paper we tackle the problem of regularisation for inverse problems in single shell diffusion weighted image restoration. Our aim is to recover a high-resolution and denoised DWI signal, prior to any model fitting. The main contribution of our metho ...

SPRINGER-VERLAG BERLIN2019

Multimodal microstructure imaging: joint T2-relaxometry and diffusometry to estimate myelin, intracellular, extracellular, and cerebrospinal fluid properties

Jean-Philippe Thiran, Alessandro Daducci, Erick Jorge Canales Rodriguez, Marco Pizzolato

We propose a multimodal joint estimation that aims at exploiting the complementary information of diffusion and multi-echo spin echo data to disentangle the contributions and properties of the main tissue microstructure compartments. We recovered T2, diffu ...

ISMRM2018

Multimodal microstructure imaging: combining relaxometry and diffusometry to estimate myelin, intracellular, extracellular, and cerebrospinal fluid properties

Jean-Philippe Thiran, Alessandro Daducci, Erick Jorge Canales Rodriguez, Marco Pizzolato

please visit https://infoscience.epfl.ch/record/264843 ...

2018

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

Jean-Philippe Thiran, Giorgio Innocenti, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Gabriel Girard, Maxime Descoteaux, Jonathan Rafael Patino Lopez

In vivo quantitative estimation of axon diameter in the white matter could bring new tools to study the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been ...

2018

Voxel size matters: big voxels are required to generate realistic extra-axonal dMRI signals from Monte Carlo simulations

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Ileana Ozana Jelescu, Jonathan Rafael Patino Lopez, Tim Bjørn Dyrby

2018