Publications de Julita Maria Stadnicka-Michalak

Predicting chemical hazard across taxa through machine learning

Julita Maria Stadnicka-Michalak, Kristin Schirmer

We applied machine learning methods to predict chemical hazards focusing on fish acute toxicity across taxa. We analyzed the relevance of taxonomy and experimental setup, showing that taking them into account can lead to considerable improvements in the cl ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Zebrafish early life stages as alternative model to study ?designer drugs?: Concordance with mammals in response to opioids

Julita Maria Stadnicka-Michalak, Kristin Schirmer

The number of new psychoactive substances (NPS) on the illicit drug market increases fast, posing a need to urgently understand their toxicity and behavioural effects. However, with currently available rodent models, NPS assessment is limited to a few subs ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Predicting exposure concentrations of chemicals with a wide range of volatility and hydrophobicity in different multi-well plate set-ups

Julita Maria Stadnicka-Michalak, Kristin Schirmer

Quantification of chemical toxicity in small-scale bioassays is challenging owing to small volumes used and extensive analytical resource needs. Yet, relying on nominal concentrations for effect determination maybe erroneous because loss processes can sign ...

NATURE RESEARCH2021

Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482

Julita Maria Stadnicka-Michalak, Mélanie Fischer, Kristin Schirmer, Anze Zupanic

ELSEVIER SCI LTD2019

Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport

Julita Maria Stadnicka-Michalak, Jianbo Zhang

The mutagen and probable human carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is metabolized in the colon to 9-hydroxyl-2,7-dimethyl-7,9,10,11-tetrahydropyrimido[2',1':2,3]imidazo[4,5-f]quinoxaline (MeIQx-M1) by conjugation with microbial ...

PERGAMON-ELSEVIER SCIENCE LTD2019

A Validated Algorithm for Selecting Non-Toxic Chemical Concentrations

Julita Maria Stadnicka-Michalak, Kristin Schirmer, Anze Zupanic

2018

Biotransformation of Benzo[a]pyrene by Three Rainbow Trout (Onchorhynchus mykiss) Cell Lines and Extrapolation To Derive a Fish Bioconcentration Factor

Julita Maria Stadnicka-Michalak, Mélanie Fischer, Kristin Schirmer

2018

Importance of Toxicokinetics to Assess the Utility of Zebrafish Larvae as Model for Psychoactive Drug Screening Using Meta-Chlorophenylpiperazine (mCPP) as Example

Julita Maria Stadnicka-Michalak, Kristin Schirmer

2018

Tralopyril bioconcentration and effects on the gill proteome of the Mediterranean mussel Mytilus galloprovincialis

Julita Maria Stadnicka-Michalak, Kevin Thomas

Antifouling (AF) systems are used worldwide as one of the most cost-effective ways of protecting submerged structures against heavy biofouling. The emergence of environmentally friendly AF biocides requires knowledge on their environmental fate and toxicit ...

Elsevier Science Bv2016

Measured and Modeled Toxicokinetics in Cultured Fish Cells and Application to In Vitro - In Vivo Toxicity Extrapolation

Julita Maria Stadnicka-Michalak, Kristin Schirmer

Effect concentrations in the toxicity assessment of chemicals with fish and fish cells are generally based on external exposure concentrations. External concentrations as dose metrics, may, however, hamper interpretation and extrapolation of toxicological ...

Public Library Science2014

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Julita Maria Stadnicka-Michalak, Kristin Schirmer

Quantification of chemical toxicity continues to be generally based on measured external concentrations. Yet, internal chemical concentrations have been suggested to be a more suitable parameter. To better understand the relationship between the external a ...

2012