Publications de Thijs Pols | EPFL Graph Search

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Alessia Perino, Vera Monica Lemos Da Silva, Laura Alejandra Velazquez Villegas, Marika Olga Zietak

Nature Research2018

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Alessia Perino

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

Probing the Binding Site of Bile Acids in TGR5

Kristina Schoonjans, Johan Auwerx, Thijs Pols

TGR5 is a G-protein-coupled receptor (GPCR) mediating cellular responses to bile acids (BAs). Although some efforts have been devoted to generate homology models of TGR5 and draw structure-activity relationships of BAs, none of these studies has hitherto d ...

American Chemical Society2013

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

Kristina Schoonjans, Johan Auwerx, Mitsunori Nomura, Thijs Pols

Wiley-Blackwell2012

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Kristina Schoonjans, Johan Auwerx, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Maaike Hélène Oosterveer, Giuseppe Lo Sasso

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Cell Press2011

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Kristina Schoonjans, Johan Auwerx, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function a ...

Elsevier2011

The bile acid membrane receptor TGR5: a valuable metabolic target

Kristina Schoonjans, Johan Auwerx, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestines as well as in the circulation depending on food intake. Besides their role in dietary lipid absorption, BAs function as signaling ...

2011

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Kristina Schoonjans, Johan Auwerx, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010