Publications de Anne Wilson | EPFL Graph Search

Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue

Nicolas Jean Philippe Guex, Marco Pagni, Anne Wilson, Aurélien Thomas, Tiziana Caputo

2021

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Nicolas Fasnacht, Freddy Radtke, Floriane Auderset, Ute Koch, Anne Wilson

Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study ...

American Association of Immunologists ; Oxford University Press2013

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility

Friedrich Beermann, Anne Wilson, Roman Chrast, Jian Wang

The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...

2012

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

Friedrich Beermann, Anne Wilson, Simona Frateschi, Roch-Philippe Charles

Altered serine protease activity is associated with skin disorders in humans and in mice. The serine protease channel-activating protease-1 (CAP1; also termed protease serine S1 family member 8 (Prss8)) is important for epidermal homeostasis and is thus in ...

Nature Research2011

Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies

Freddy Radtke, Floriane Auderset, Ute Koch, Anne Wilson

It is well established that Notch signaling plays a critical role at multiple stages of T cell development and activation. However, detailed analysis of the cellular and molecular events associated with Notch signaling in T cells is hampered by the lack of ...

2009

Selective Requirement for c-Myc at an Early Stage of V alpha 14i NKT Cell Development

Anne Wilson, Wei Jiang

V alpha 14 invariant (V alpha 14i) NKT cells are a subset of regulatory T cells that utilize a semi-invariant TCR to recognize glycolipids associated with monomorphic CD1d molecules. During development in the thymus, CD4(+)CD8(+) V alpha 14i NKT precursors ...

American Association of Immunologists ; Oxford University Press2009

Dormant and Activated Stem Cells during Homeostasis Injury and Cancer

Anne Wilson

2009

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

Armin Ehninger, Anne Wilson

Myc activity is emerging as a key element in acquisition and maintenance of stem cell properties. We have previously shown that c-Myc deficiency results in accumulation of defective hematopoietic stem cells (HSCs) due to niche-dependent differentiation def ...

2008

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Cyrille Dunant, Maike Jaworski, Sandra Eloise Kjeldsen, Anne Wilson

Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit ...

2008

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

Freddy Radtke, Ute Koch, Anne Wilson

Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self- ...

2008

Haematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

Anne Wilson

2008

Dormant and self-renewing hematopoietic stem cells and their niches

Maike Jaworski, Anne Wilson

In the mouse, over the last 20 years, a set of cell-surface markers and activities have been identified, enabling the isolation of bone marrow (BM) populations highly enriched in hematopoietic stem cells (HSCs). These HSCs have the ability to generate mult ...

2007

Multiple functions of Notch signaling in self-renewing organs and cancer

Freddy Radtke, Anne Wilson

In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often ...

2006

Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila

Freddy Radtke, Anne Wilson

The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of ...

2005

Paradigms of notch signaling in mammals

Freddy Radtke, Anne Wilson

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. These proteins are involved in organogenesis during embryonic development as well as in the maintenance of homeostasis of self-re ...

2005