Publications de Ilaria Mosconi

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Luc Xavier Marie Lebon, Ilaria Mosconi, Nicola Harris, Lalit Kumar Dubey

Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted ...

Elsevier2016

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Alexis Rapin, Jacques Rougemont, Laure Menin, Luc Xavier Marie Lebon, Ilaria Mosconi, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Lalit Kumar Dubey, Alessandra Piersigilli, Andrew J. Macpherson

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Luc Xavier Marie Lebon, Ilaria Mosconi, Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Beatrice Volpe, Lalit Kumar Dubey

Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regula ...

American Society for Microbiology2015

Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation

Ilaria Mosconi, Nicola Harris, Benjamin John Marsland

BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...

Wiley-Blackwell2014

Regulatory T cells modulate the intestinal immune response in homeostasis and infection

Ilaria Mosconi

EPFL2014

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

Ilaria Mosconi, Nicola Harris, Mario Michael Zaiss

Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is known to regulate inflammation in models of colitis. We show that steady-state TSLP expression requires intestinal bacteria and has an important role in limiting the ex ...

Nature Publishing Group2013

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

Nadine Guenat, Ilaria Mosconi, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution ...

Public Library Science2013

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

Fei Chen, Arne Seitz, Ilaria Mosconi, Nicola Harris, Julia Esser-von Bieren, Romain Guiet, Beatrice Volpe, Alessandra Piersigilli

Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against chall ...

Public Library of Science2013

Role of thymic stromal lymphopoietin (TSLP) signaling in intestinal immune homeostasis

Ilaria Mosconi

2011