Publications de Philipp Sebastian Lienemann

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

Matthias Lütolf, Vincent Milleret, Aline Roch, Stéphanie Elisabeth Metzger, Philipp Sebastian Lienemann, Martin Ehrbar, Olaia Maria Naveiras Torres-Quiroga, Panagiota Papageorgiou, Queralt Vallmajó Martín, Manuel Koch

The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mob ...

WILEY2020

Locally controlling mesenchymal stem cell morphogenesis by 3D PDGF-BB gradients towards the establishment of an in vitro perivascular niche

Matthias Lütolf, Vincent Milleret, Yannick Robert Devaud, Philipp Sebastian Lienemann, Martin Ehrbar

The perivascular niche is a complex microenvironment containing mesenchymal stem cells (MSCs), among other perivascular cells, as well as temporally organized biochemical and biophysical gradients. Due to a lack of conclusive phenotypic markers, MSCs' iden ...

Royal Soc Chemistry2015

Electrochemical Control of the Enzymatic Polymerization of PEG Hydrogels: Formation of Spatially Controlled Biological Microenvironments

Vincent Milleret, Philipp Sebastian Lienemann, Martin Ehrbar

Wiley-Blackwell2014

3D growth factor patterned cell substrates to locally control cellular behavior

Matthias Lütolf, Vincent Milleret, Yannick Robert Devaud, Philipp Sebastian Lienemann, Martin Ehrbar

Wiley-Blackwell2014

Tissue Engineering Bone by Matrix-Assisted MSC Recruitment

Philipp Sebastian Lienemann

EPFL2014

Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity

Philipp Sebastian Lienemann, Martin Ehrbar

The precise manipulation of growth factor signaling is central to the progress of tissue engineering. Methods for direct time-resolved activation of signaling pathways through controlled receptor dimerization have been reported; however, these suffer from ...

Nature Publishing Group2013

A Versatile Approach to Engineering Biomolecule-Presenting Cellular Microenvironments

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

Wiley-Blackwell2013

Engineering biomimetic hydrogels for induced recruitment of mesenchymal stem cells in vitro and in vivo

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar, Olaia Maria Naveiras Torres-Quiroga

Wiley-Blackwell2012

Keynote: Engineering homing and differentiation of mesenchymal progenitor cells during bone healing

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

Wiley-Blackwell2012

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

Matthias Lütolf, Katarzyna Mosiewicz, Adrian Ranga, Philipp Sebastian Lienemann, Martin Ehrbar

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating ...

Elsevier2011