Jocelin Grosse

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Publications associées (28)

Neuroligin-2 expression in the prefrontal cortex is involved in attention deficits induced by peripubertal stress

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Olivia Zanoletti, Jocelin Grosse, Orbicia Riccio Wicht

Emerging evidence indicates that attention deficits, which are frequently observed as core symptoms of neuropsychiatric disorders, may be elicited by early life stress. However, the mechanisms mediating these stress effects remain unknown. The prefrontal c ...

2016

The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Michael van der Kooij

Infancy is a critical period for brain development. Emerging evidence indicates that stress experienced during that period can have long-term programming effects on the brain and behavior. However, whether different time periods represent different vulnera ...

2015

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Céline Fournier, Alexandre Claude Gustave Bacq

Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associ ...

2015

Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression

Maria del Carmen Sandi Perez, Martina Fantin, Olivia Zanoletti, Jocelin Grosse, Michael van der Kooij

Neuroligins (NLGNs) are cell adhesion molecules that are important for proper synaptic formation and functioning and are critical regulators of the balance between neural excitation/inhibition (E/I). Mutations in NLGNs have been linked to psychiatric disor ...

Nature Publishing Group2014

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Maria del Carmen Sandi Perez, Martina Fantin, Olivia Zanoletti, Jocelin Grosse, Michael van der Kooij, Céline Fournier

Chronic stress is a risk factor for the development of psychopathologies characterized by cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests a role for cell adhesion molecules, including nectin-3, in the mechanisms that un ...

Nature Research2014

Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Céline Fournier, Orbicia Riccio Wicht

Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional be ...

Public Library of Science2013

A key role for nectin-1 in the ventral hippocampus in contextual fear memory

Maria del Carmen Sandi Perez, Martina Fantin, Jocelin Grosse, Michael van der Kooij

Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-int ...

Public Library of Science2013

The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Céline Fournier, Orbicia Riccio Wicht

The neural cell adhesion molecule (NCAM) is a key regulator of brain plasticity. Substantial evidence indicates that NCAM is down-regulated by exposure to sustained stress and chronic stress seems to lead to increased aggression. In addition, constitutiona ...

Informa Healthcare2013

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