Publications de Federico Tortelli

Extracellular matrix heparin-binding domains

Mikaël Martino, Jeffrey Alan Hubbell, Jeffrey James Rice, Federico Tortelli

Heparin binding peptides derived from a Tenascin (TNC) III1-5 domain or a fibrinogen ²15-66 domain have been found that bind certain cytokines with high affinity. Materials and methods for making compositions and devices using these peptides are disclosed. ...

2015

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Stéphanie Elisabeth Metzger, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Jeffrey James Rice, Esra Güç, Federico Tortelli

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

American Association for the Advancement of Science2014

Growth factors engineered for super-affinity to extracellular matrix enhance tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Federico Tortelli

Wiley-Blackwell2014

Extracellular matrix molecules regulate growth factor and cytokine delivery through their heparin-binding domains and promote wound healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Wiley-Blackwell2014

Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain

Jeffrey Alan Hubbell, Jeffrey James Rice, Federico Tortelli

Tenascin C (TNC) is an extracellular matrix protein that is upregulated during development as well as tissue remodeling. TNC is comprised of multiple independent folding domains, including 15 fibronectin type III-like (TNCIII) domains. The fifth TNCIII dom ...

Public Library of Science2013

Silk Hydrogels as Soft Substrates for Neural Tissue Engineering

Jeffrey Alan Hubbell, Federico Tortelli, Amy Marie Hopkins

There is great need for soft biomaterials that match the stiffness of human tissues for tissue engineering and regeneration. Hydrogels are frequently employed for extracellular matrix functionalization and to provide appropriate mechanical cues. It is chal ...

Wiley-V C H Verlag Gmbh2013

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

Engineering the Regenerative Microenvironment with Biomaterials

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Jeffrey James Rice, Federico Tortelli

Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-tempor ...

Wiley-Blackwell2013

Exploring the growth factor-binding properties of osteopontin

Mikaël Martino, Jeffrey Alan Hubbell, Federico Tortelli

Wiley-Blackwell2012

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Mayumi Mochizuki Martino, Federico Tortelli

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011