Publications de Tim Vogels | EPFL Graph Search

Mapping the function of neuronal ion channels in model and experiment

Rajnish Ranjan, Alexander Kevin Seeholzer, Tim Vogels, William Francis Podlaski

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison o ...

Elife Sciences Publications Ltd2017

Connection-type-specific biases make uniform random network models consistent with cortical recordings

Wulfram Gerstner, Carl Petersen, Michael Avermann, Christian Tomm, Tim Vogels

Uniform random sparse network architectures are ubiquitous in computational neuroscience, but the implicit hypothesis that they are a good representation of real neuronal networks has been met with skepticism. Here we used two experimental data sets, a stu ...

American Physiological Society2014

Optimal Control of Transient Dynamics in Balanced Networks Supports Generation of Complex Movements

Wulfram Gerstner, Guillaume Hennequin, Tim Vogels

Populations of neurons in motor cortex engage in complex transient dynamics of large amplitude during the execution of limb movements. Traditional network models with stochastically assigned synapses cannot reproduce this behavior. Here we introduce a clas ...

Cell Press2014

Inhibitory synaptic plasticity: spike timing-dependence and putative network function

Friedemann Zenke, Tim Vogels

While the plasticity of excitatory synaptic connections in the brain has been widely studied, the plasticity of inhibitory connections is much less understood. Here, we present recent experimental and theoretical findings concerning the rules of spike timi ...

Frontiers Research Foundation2013

Non-normal amplification in random balanced neuronal networks

Wulfram Gerstner, Guillaume Hennequin, Tim Vogels

In dynamical models of cortical networks, the recurrent connectivity can amplify the input given to the network in two distinct ways. One is induced by the presence of near-critical eigenvalues in the connectivity matrix W, producing large but slow activit ...

2012

Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks

Wulfram Gerstner, Claudia Clopath, Friedemann Zenke, Tim Vogels

Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an expla ...

American Association for the Advancement of Science2011