Publications de Camilla Baj-Rossi

An Innovative System of Membranes for the Monitoring of Endogenous and Exogenous Metabolites

Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

The development of a low-cost, robust, and versatile biosensors for the rapid detection of endogenous and exogenous metabolites in small animals is of great interest for health-care, pharmaceuticals, and in translational medicine. This work presents a comp ...

Springer2016

In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

Catherine Dehollain, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Francesca Stradolini

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in ...

Ieee-Inst Electrical Electronics Engineers Inc2016

Wireless Monitoring of Endogenous and Exogenous Biomolecules on an Android Interface

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Irene Taurino, Camilla Baj-Rossi, Grégoire Casimir Joseph Surrel, Stefano Riario, Francesca Stradolini

Monitoring patients in intensive care units is generally expensive and time consuming. A prompter medical intervention for those critical patients is a key factor for their safety. Therefore, a system that offers immediate visualization of the monitored da ...

Institute of Electrical and Electronics Engineers2016

A System for Wireless Power Transfer and Data Communication of Long-Term Bio-Monitoring

Catherine Dehollain, Giovanni De Micheli, Cristina Boero, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Franco Maloberti, Stefano Riario, Francesca Stradolini

A system for wireless power transfer and data communication of implantable bio-monitoring systems is presented. The proposed solution uses a servo-controlled power transmitter moved under the animal moving space. An x-y movable magnetic coil transmits the ...

Institute of Electrical and Electronics Engineers2015

A neural approach to drugs monitoring for personalized medicine

Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi, Marius Schirmer

The development of fast and mobile drug detection is an important aspect of personalized medicine. It enables the quick assessment of inter-individual differences in drug metabolism and corresponding adjustments of the dose. Recent developments of amperome ...

2015

Biocompatible Packagings for Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi, Francesco Grassi

This paper compares three different biocompatible packagings suitable to support full implantation of multi-panel sensors for remote monitoring of metabolism. The three packagings have been designed, realized and implanted in mice for 30 days. ATP and neut ...

2015

Faradic Peaks Enhanced by Carbon Nanotubes in Microsomal Cytochrome P450 Electrodes

Christian Müller, Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi

In this work we present an investigation on the behavior of microsomes containing human cytochrome P450 in cyclic voltammetry for drug detection. The microsomes are adsorbed on the surface of multi-walled carbon nanotubes by drop-casting. We demonstrate th ...

Wiley-Blackwell2015

Implantable Multi-panel Platform for Continuous Monitoring of Exogenous and Endogenous Metabolites for Applications in Personalized Medicine

Camilla Baj-Rossi

Nowadays, scientific advances are leading to the discovery of newer, better, more targeted treatments that will improve the human health. However, despite the promising results and the major advantages in treatments offered to patients, these personalized ...

EPFL2015

Full System for Translational Studies of Personalized Medicine with Free-Moving Mice (invited)

Catherine Dehollain, Giovanni De Micheli, Cristina Boero, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Grégoire Casimir Joseph Surrel, Stefano Riario, Francesca Stradolini

A full remotely powered system for metabolism monitoring of free-moving mice is presented here. The fully implantable sensing platform hosts two ASICs, one off-the-shelf micro-controller, four biosensors, two other sensors, a coil to receive power, and an ...

2015

An Integrated Control and Readout Circuit for Implantable Multi-Target Electrochemical Biosensing

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

We describe an integrated biosensor capable of sensing multiple molecular targets using both cyclic voltammetry (CV) and chronoamperometry (CA). In particular, we present our custom IC to realize voltage control and current readout of the bio ...

2014

Do Carbon Nanotubes Contribute to Electrochemical Biosensing?

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Camilla Baj-Rossi

Carbon nanotubes have been attracting a lot of interest as electron transfer mediators to enhance electrochemical biosensing. The main reason behind this is usually recognized in terms of augmented electrochemical active surface area. The aim of this paper ...

Elsevier2014

Memristive Biosensors Under Varying Humidity Conditions

Yusuf Leblebici, Giovanni De Micheli, Davide Sacchetto, Sandro Carrara, Camilla Baj-Rossi, Francesca Puppo, Akshat Dave

We attempt to examine the potential of silicon nanowire memristors in the field of nanobiosensing. The mem- ristive devices are crystalline Silicon (Si) Nanowires (NWs) with Nickel Silicide (NiSi) terminals. The nanowires are fabricated on a Silicon-on-Ins ...

Institute of Electrical and Electronics Engineers2014

Sub-mW Reconfigurable Interface IC for Electrochemical Sensing

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

The IronIC project has the aim of developing a fully implantable and remotely powered platform for the real- time monitoring of human metabolites. In this paper we present a mixed-signal interface IC for the electrochemical sensing data acquisition chain. ...

IEEE2014

Full Fabrication and Packaging of an Implantable Multi-panel Device for Monitoring of Metabolites in Small Animals

Catherine Dehollain, Giovanni De Micheli, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Daniele Casarino

In this work, we show the realization of a fully-implantable device for monitoring free-moving small animals. The device integrates a microfabricated sensing platform, a coil for power and data transmission and two custom designed integrated circuits. The ...

Ieee-Inst Electrical Electronics Engineers Inc2014

Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor

Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Camilla Baj-Rossi

This paper reports the characterization of an electrochemical biosensor for the continuous monitoring of Naproxen based on cytochrome P450. The electrochemical biosensor is based on the drop-casting of multi-walled carbon-nanotubes (MWCNTs) and microsomal ...

Elsevier2014

A Linear Approach to Multi-Panel Sensing in Personalized Therapy for Cancer Treatment

Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi

In this paper, a new approach for evaluating the performance of a multi-panel biosensor using linear algebra is presented. With a system-level mathematical analysis based on graphs and linear algebra, we formulate a new approach for contributions decouplin ...

Institute of Electrical and Electronics Engineers2013

An Implantable Bio-Micro-system for Drug Monitoring

Catherine Dehollain, Giovanni De Micheli, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

Multi-target and continuous monitoring by wireless implantable devices is of increasing interest for personalized therapy. In this work an implantable system is presented which is capable of measuring different drugs with Cyclic Voltammetry (CV) method. Th ...

2013

Fabrication and Packaging of a Fully Implantable Biosensor Array

Catherine Dehollain, Giovanni De Micheli, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Daniele Casarino

In this work, we showed the realization of a fully- implantable device that integrates a microfabricated sensing platform, a coil for power and data transmission and integrated circuits. We described a device intended to test the biocompati- bility of the ...

2013

Integrated Biosensors for Personalized Medicine

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Irene Taurino, Camilla Baj-Rossi

Biosensors are heterogenous devices, incorporating biological struc- tures combined with electronics, optical or other readout systems. They have been developed for detecting different biomolecules and/or pathogens and represent a key technology for advanc ...

Ieee2012

Memristive-Biosensors: A New Detection Method by Using Nanofabricated Memristors

Yusuf Leblebici, Giovanni De Micheli, Davide Sacchetto, Sandro Carrara, Camilla Baj-Rossi

This paper proposes a new detection methodology based on memristive-effect registered on silicon nanowire. The nano-wires are fabricated by a lithographic technique that allows precise and selective etching at the nanoscale. The wires are obtained in three ...

Elsevier2012