Publications de Dani Osman | EPFL Graph Search

Enteric infection induces Lark-mediated intron retention at the 5 ' end of Drosophila genes

Michael Vincent Frochaux, Bart Deplancke, Dani Osman, Maroun Bou Sleiman, Tommaso Andreani

Background RNA splicing is a key post-transcriptional mechanism that generates protein diversity and contributes to the fine-tuning of gene expression, which may facilitate adaptation to environmental challenges. Here, we employ a systems approach to study ...

2020

Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells

Jean Philippe Boquete, Bruno Lemaitre, Dani Osman

Adult stem cells must continuously fine‐tune their behavior to regenerate damaged organs and avoid tumors. While several signaling pathways are well known to regulate somatic stem cells, the underlying mechanisms remain largely unexplored. Here, we demonst ...

Springer Science and Business Media LLC2020

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

Michael Vincent Frochaux, Bart Deplancke, Dani Osman, Maroun Bou Sleiman, Tommaso Andreani, Riccardo Dainese, Virginie Sandra Braman, Vincent Roland Julien Gardeux, Maria Litovchenko, Brian Dennis Hollis

Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...

2020

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Bruno Lemaitre, Bart Deplancke, Andreas Massouras, Dani Osman, Maroun Bou Sleiman

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium ...

Nature Publishing Group2015

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Bart Deplancke, Dani Osman

Although the gut is a central organ of Eumetazoans and is essential for organismal health, our understanding of its morphological and molecular determinants remains rudimentary. Here, we provide a comprehensive atlas of Drosophila adult midgut. Specificall ...

Elsevier2013

Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division

Bruno Lemaitre, Sveta Chakrabarti, Dani Osman, Yu-Chen Tsai, Yu-Ting Huang

The Janus Kinase (JAK) Signal Transducer and Activator of Transcription (STAT) pathway is involved in the regulation of Intestinal Stem Cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired1, 2 and 3 are ...

Company Of Biologists Ltd2012