Publications de Tim Rolf Eichhorn

Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri

Arnaud Comment, Christophe Roussel, Tim Rolf Eichhorn

A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in ...

2016

Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Arnaud Comment, Jacques Van Der Klink, Giovanni Boero, Christophe Roussel, Tian Cheng, Tim Rolf Eichhorn, Jean-Noël Hyacinthe, Andrea Capozzi

Hyperpolarization via dissolution dynamic nuclear polarization (DNP) is a versatile method to dramatically enhance the liquid-state NMR signal of X-nuclei and can be used for performing metabolic and molecular imaging. It was recently demonstrated that ins ...

American Chemical Society2015

Dynamic nuclear polarisation via the integrated solid effect II: experiments on naphthalene-h(8) doped with pentacene-d(14)

Tim Rolf Eichhorn

In dynamic nuclear polarisation (DNP), also called hyperpolarisation, a small amount of unpaired electron spins is added to the sample containing the nuclear spins, and the polarisation of these unpaired electron spins is transferred to the nuclear spins b ...

Taylor & Francis2014

Proton polarization above 70% by DNP using photo-excited triplet states, a first step towards a broadband neutron spin filter

Tim Rolf Eichhorn

The use of polarized protons as neutron spin filter is an attractive alternative to the well established neutron polarization techniques, as the large, spin-clepenclent neutron scattering cross-section for protons is useful up to the sub-MeV region. Employ ...

Elsevier2014

Dynamic Nuclear Polarization with Paramagnetic Centers Created by Photo-Excitation

Tim Rolf Eichhorn

EPFL2014

Purely endogenous hyperpolarized [1-13C]Pyruvate solutions for metabolic study in glioblastoma rat models

Arnaud Comment, Rolf Gruetter, Mor-Miri Mishkovsky, Tim Rolf Eichhorn, Emine Can

2014

Hyperpolarization of 129Xe by sublimation DNP using photo-activated radical precursors

Arnaud Comment, Christophe Roussel, François Lazeyras, Tim Rolf Eichhorn, Jean-Noël Hyacinthe, Najat Salameh, Andrea Capozzi

2013

An apparatus for pulsed ESR and DNP experiments using optically excited triplet states down to liquid helium temperatures

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Tim Rolf Eichhorn, Martin Haag

In standard Dynamic Nuclear Polarization (DNP) electron spins are polarized at low temperatures in a strong magnetic field and this polarization is transferred to the nuclear spins by means of a microwave field. To obtain high nuclear polarizations cryogen ...

Academic Press2013

High proton spin polarization with DNP using the triplet state of pentacene-d14

Tim Rolf Eichhorn

The proton spins in a large naphthalene single crystal have been very efficiently polarized using optically excited triplet states of fully deuterated pentacene (C22D14) guest molecules. In a field of 0.3 T a proton polarization of 0.50 has been achieved. ...

Elsevier2013

Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Arnaud Comment, Christophe Roussel, Mor-Miri Mishkovsky, Tian Cheng, Tim Rolf Eichhorn, Yuhei Takado, Jean-Noël Hyacinthe, Najat Salameh, Andrea Capozzi

Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure diagnosis and therapy monitoring through the detection of metabolic impairments in v ...

National Academy of Sciences2013

Spin filtering neutrons with a proton target dynamically polarized using photo-excited triplet states

Tim Rolf Eichhorn

In a test of principle a neutron spin filter has been built, which is based on dynamic nuclear polarization (DNP) using photo-excited triplet states. This DNP method has advantages over classical concepts as the requirements for cryogenic equipment and mag ...

2012