Publications de Florian Dylan Fallegger

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

Florian Dylan Fallegger, Stéphanie Lacour, Florent-Valéry Coen, Emilie Cornelia Maria Revol, Ivan Furfaro, Laurine Kolly, Jocelyne Bloch, Alix Esther Anne Trouillet

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engi ...

2025

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Florian Dylan Fallegger, Stéphanie Lacour, Silvestro Micera, Katia Galan, Ivan Furfaro, Valentina Marie Paggi, Olivier Didier Christian Rizzo

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

Implantable electrical/electronic biomedical device, system and methods for using the same

Ludovic Serex, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Sukho Song

It is disclosed an implantable electrical/electronic biomedical device comprising: a) a reservoir (100) comprising an inlet (101) at a first end and a mechanical support (200) at a second, opposed end, and b) at least one electrode structure (300) deployab ...

2023

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Florent-Valéry Coen, Alix Esther Anne Trouillet

Interfacing the human body with the next generation of electronics requires technological advancement in designing and producing bioelectronic circuits. These circuits must integrate electrical functionality while simultaneously addressing limitations in m ...

2023

Deployment of an electrocorticography system with a soft robotic actuator

Florian Dylan Fallegger, Stéphanie Lacour, Sukho Song, Kyungjin Kim, Alix Esther Anne Trouillet

Electrocorticography (ECoG) is a minimally invasive approach frequently used clinically to map epileptogenic regions of the brain and facilitate lesion resection surgery and increasingly explored in brain-machine interface applications. Current devices dis ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Florian Dylan Fallegger, Stéphanie Lacour, Alix Esther Anne Trouillet

Neurological impairments and diseases can be diagnosed or treated using electrocorticography (ECoG) arrays. In drug-resistant epilepsy, these help delineate the epileptic region to resect. In long-term applications such as brain-computer interfaces, these ...

JOURNAL OF VISUALIZED EXPERIMENTS2023

Method for labelling a device and devices obtanaible therefrom

Ludovic Serex, Nicolas Vachicouras, Florian Dylan Fallegger

Disclosed herein is a method for labelling a portion of a device, said method comprising the steps of providing a first substrate layer of a transparent or translucent material, depositing a first coloured material onto said first substrate layer in a labe ...

2022

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Tomislav Milekovic, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Katia Galan, Jocelyne Bloch, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

A 16-Channel Neural Recording System-on-Chip With CHT Feature Extraction Processor in 65-nm CMOS

Catherine Dehollain, Yusuf Leblebici, Volkan Cevher, Florian Dylan Fallegger, Stéphanie Lacour, Cosimo Aprile, Kerim Türe, Emilie Cornelia Maria Revol, Arda Uran, Alix Esther Anne Trouillet

Next generation invasive neural interfaces require fully implantable wireless systems that can record from a large number of channels simultaneously. However, transferring the recorded data from the implant to an external receiver emerges as a significant ...

2022

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

MRI-Compatible and Conformal Electrocorticography Grids for Translational Research

Giuseppe Schiavone, Ludovic Serex, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Fabien Bertrand Paul Wagner

Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized elec ...

2021

Viscoelastic surface electrode arrays to interface with viscoelastic tissues

Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Christina Myra Tringides, Alix Esther Anne Trouillet

Bioelectronic interfacing with living tissues should match the biomechanical properties of biological materials to reduce damage to the tissues. Here, the authors present a fully viscoelastic microelectrode array composed of an alginate matrix and carbon-b ...

Nature Research2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Nathan Antoine Greiner, Simon Borgognon, Nicholas David James, Henri Charles Alexandre Lorach

Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting t ...

Nature Research2021

Hybrid soft-rigid electrical interconnection system

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or withi ...

2021

A 16-Channel Wireless Neural Recording System-on-Chip with CHT Feature Extraction Processor in 65nm CMOS

Catherine Dehollain, Yusuf Leblebici, Volkan Cevher, Florian Dylan Fallegger, Stéphanie Lacour, Cosimo Aprile, Kerim Türe, Arda Uran, Alix Esther Anne Trouillet

Wireless implantable neural recording chips enable multichannel data acquisition with high spatiotemporal resolution in situ. Recently, the use of machine learning approaches on neural data for diagnosis and prosthesis control have renewed the interest in ...

2021

Soft, Implantable Bioelectronic Interfaces for Translational Research

Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Evgenia Vladimirova Roussinova, Ivan Furfaro, Andreas Rowald, Beatrice Barra, Simon Borgognon, Jocelyne Bloch, Xiaoyang Kang, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Integration of hybrid material systems in conformable neural interfaces

Florian Dylan Fallegger

Neural interfaces are devices that are implanted into the body and interface electrically with the central (CNS) or peripheral nervous system. They are inserted surgically for short periods of time or chronically to diagnose or treat several neural disease ...

EPFL2020

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, and assist in reversing conditions such as deafness, blindness, and ...

Wiley2020

Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation

Jérôme Gandar, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Xiaoyang Kang

2020