Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy production. However, whether this change in the metabolic program is the cause ...

Nature Publishing Group2016

Methods & compounds useful in hematopoietic stem cell medicine

Matthias Lütolf, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga

The present invention relates to a specific marker for stem cells having long-term multi-lineage blood reconstitution capability and uses thereof for the preparation of cell composition in view of hematopoietic stem cell medicine and in particular regenera ...

2016

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis

Nan Li, Olaia Maria Naveiras Torres-Quiroga

Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we show that fluid shear stress endows ...

2015

Mitochondrial Activity Determines Hematopoietic Stem Cell Fate Decisions

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2014

The transcriptional landscape of hematopoietic stem cell ontogeny

Olaia Maria Naveiras Torres-Quiroga

Transcriptome analysis of adult hematopoietic stem cells (HSCs) and their progeny has revealed mechanisms of blood differentiation and leukemogenesis, but a similar analysis of HSC development is lacking. Here, we acquired the transcriptomes of developing ...

2012

Engineering biomimetic hydrogels for induced recruitment of mesenchymal stem cells in vitro and in vivo

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar, Olaia Maria Naveiras Torres-Quiroga

Wiley-Blackwell2012

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Richardus Houtkooper, Mukul Girotra, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2012

Epigenetic memory in induced pluripotent stem cells

Olaia Maria Naveiras Torres-Quiroga, Kyungjin Kim, Ji Hyun Kim

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, these two reprogramming methods ...

2010

Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells

Olaia Maria Naveiras Torres-Quiroga

Surface antigens on hematopoietic stem cells (HSCs) enable prospective isolation and characterization. Here, we compare the cell-surface phenotype of hematopoietic repopulating cells from murine yolk sac, aorta-gonad-mesonephros, placenta, fetal liver, and ...

2009

Biomechanical forces promote embryonic haematopoiesis

Olaia Maria Naveiras Torres-Quiroga

Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the developing cardiovascular system. After initiation of the heartbeat in vertebrates, cells lining the ventral aspect of the dorsal aorta, the placental vessels, a ...

2009

ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines

Olaia Maria Naveiras Torres-Quiroga

Interferon (IFN) is effective at inducing complete remissions in patients with chronic myelogenous leukemia (CML), and evidence supports an immune mechanism. Here we show that the type I IFNs (alpha and beta) regulate expression of the IFN consensus sequen ...

2009

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Olaia Maria Naveiras Torres-Quiroga

Osteoblasts and endothelium constitute functional niches that support haematopoietic stem cells in mammalian bone marrow. Adult bone marrow also contains adipocytes, the number of which correlates inversely with the haematopoietic activity of the marrow. F ...

2009

The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells

Olaia Maria Naveiras Torres-Quiroga

Embryonic stem cells (ESCs) differentiated in vitro will yield a multitude of hematopoietic derivatives, yet progenitors displaying true stem cell activity remain difficult to obtain. Possible causes are a biased differentiation to primitive yolk sac-type ...

Wiley-Blackwell2007

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway

Olaia Maria Naveiras Torres-Quiroga, Zhao Chen

The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types. Defective myosin-IIA complexes are presumed to perturb megakaryocyte (MK) differentiati ...

American Society of Hematology2007

Method of enhancing proliferation and/or hematopoietic differentiation of stem cells

Olaia Maria Naveiras Torres-Quiroga

The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hema ...

2007

Stem cells and their niche: a matter of fate

Olaia Maria Naveiras Torres-Quiroga

Embryonic stem cells provide an in vitro model for developmental biologists to study cell fate decisions during ontogenesis, while somatic stem cells allow physiologists to understand tissue homeostasis in the adult. The behavior of stem cells is dependent ...

Springer Verlag2006

Embryonic stem cell-derived hematopoietic stem cells

Olaia Maria Naveiras Torres-Quiroga

Despite two decades of studies documenting the in vitro blood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exp ...

National Academy of Sciences2005

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