Publications de Paulo Henrique Jacob Silva

Structure-Activity Relationship Studies of Glycosaminoglycan Mimetic Macrocycles Against Herpes

Francesco Stellacci, Paulo Henrique Jacob Silva

The herpes simplex virus (HSV) is associated with serious conditions, such as encephalitis and blindness, and its infection is closely linked to significant vascular complications and coagulation issues, particularly in individuals with compromised immune ...

AMER CHEMICAL SOC2025

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Francesco Stellacci, Paulo Henrique Jacob Silva, Lixia Wei, Matteo Gasbarri, Yong Zhu, Heyun Wang

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

Amer Chemical Soc2024

Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral drug

Aurélien Bornet, Francesco Stellacci, Paulo Henrique Jacob Silva

Increasing resistance to antiviral drugs approved for the treatment of influenza urges the development of novel compounds. Ideally, this should be complemented by a careful consideration of the administration route. 6′siallyllactosamine-functionalized β-cy ...

2024

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses

Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu

In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representin ...

2024

Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

Francesco Stellacci, Paulo Henrique Jacob Silva, Marine Batista, Yong Zhu, Andrey Sysoev

We have reported that CD-6'SLN [6-sialyllactosamine (6'SLN)-modified beta-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6'SLN improved mice survival in an H1N1 infection model eve ...

MDPI2023

Simultaneous Electrophysiology and Imaging Reveal Changes in Lipid Membrane Thickness and Tension upon Uptake of Amphiphilic Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Camilla Servidio, Xufeng Xu

Amphiphilic gold core nanoparticles (AmNPs) striped with hydrophilic 11-mercapto-1-undecanesulfonate (MUS) and hydrophobic 1-octanethiol (OT) ligands are promising candidates for drug carriers that passively and nondisruptively enter cells. Yet, how they i ...

Amer Chemical Soc2023

Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Heyun Wang, Xufeng Xu, Rémi Andréa La Polla

We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...

Academic Press Inc Elsevier Science2023

Development of an inhalable antiviral powder formulation against respiratory syncytial virus

Daniel Ortiz Trujillo, Francesco Stellacci, Paulo Henrique Jacob Silva, Matteo Gasbarri

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection ...

ELSEVIER2023

Amphiphilic Au nanoparticles and cholesterol-containing liposomes serving as minimal tunable fusion machinery

Francesco Stellacci, Paulo Henrique Jacob Silva, Ester Canepa, Giulia Rossi

SPRINGER2023

Reversible Microscale Assembly of Nanoparticles Driven by the Phase Transition of a Thermotropic Liquid Crystal

Holger Frauenrath, Stephen Schrettl, Francesco Stellacci, Paulo Henrique Jacob Silva, Kellen Michael Harkness

The arrangement of nanoscale building blocks into patternswithmicroscale periodicity is challenging to achieve via self-assemblyprocesses. Here, we report on the phase-transition-driven collectiveassembly of gold nanoparticles in a thermotropic liquid crys ...

AMER CHEMICAL SOC2023

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Francesco Stellacci, Paulo Henrique Jacob Silva, Ester Canepa, Giulia Rossi

Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

WILEY-V C H VERLAG GMBH2023

Site-selective overgrowth of Ag nanocrystals by Polyvinylpyrrolidone-mediated atom deposition by Ostwald ripening

Francesco Stellacci, Paulo Henrique Jacob Silva, Alejandro Lapresta Fernandez

The growth modulation of metal nanocrystals (NCs) by Ostwald ripening (OR) involves control of the relocation of matter by diffusional mass transfer from the dissolution of small nanocrystals (SNCs) towards large nanocrystals whose surface energy is lower. ...

ELSEVIER2022

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Francesco Stellacci, Paulo Henrique Jacob Silva, Lixia Wei, Corey Alfred Stevens, Lukasz Richter

One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a ...

AMER CHEMICAL SOC2022

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions

Davide Demurtas, Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Anna Murello, Ting Mao, Francesca Olgiati, Xufeng Xu

Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles ( ...

2022

Experimental Method to Distinguish between a Solution and a Suspension

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Ting Mao, Xufeng Xu

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, Delta G(mix) < 0) or suspensions (Delta G(mix) > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones suspension ...

WILEY2022

Site-selective surface enhanced Raman scattering study of ligand exchange reactions on aggregated Ag nanocubes

Francesco Stellacci, Paulo Henrique Jacob Silva, Zekiye Pelin Güven, Evangelia-Nefeli Athanasopoulou

Surface modification of ligand protected nanoparticles (NPs) can be driven by ligand exchange reactions (LER). Little is known about the mechanism of this reaction, especially when the particles are not spherical. Here, we use the intrinsic hot spots gener ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Virucidal compositions and use thereof

Francesco Stellacci, Paulo Henrique Jacob Silva, Özgün Kocabiyik, Valeria Cagno

The invention relates to virucidal compositions comprising a sialic acid (SA) moiety, pharmaceutical compositions and disinfection and/or sterilization compositions comprising thereof and uses thereof in disinfection and/or sterilization methods and in tre ...

2021

Broad-spectrum nanoparticles against bacteriophage infections

Francesco Stellacci, Paulo Henrique Jacob Silva, Zekiye Pelin Güven, Urszula Beata Cendrowska, Matteo Gasbarri, Lukasz Richter, Francesca Olgiati

Viral infections caused by bacteriophages, i.e., viruses that kill bacteria are one of the most dangerous and common threats for bacteria-based bioreactors. More than 70% of biotechnology companies have admitted to encountering this problem. Despite phage ...

ROYAL SOC CHEMISTRY2021

Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir

Francesco Stellacci, Paulo Henrique Jacob Silva, Chiara Medaglia

Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics. Influenza viruses also possess a high genetic variabi ...

2021

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

Francesco Stellacci, Paulo Henrique Jacob Silva

The deposition of amyloid-beta (A beta) plaques in the brain is a significant pathological signature of Alzheimer's disease, correlating with synaptic dysfunction and neurodegeneration. Several compounds, peptides, or drugs have been designed to redirect o ...

2020