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Laurent Mouchiroud

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Publications associées (36)

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Shreya Narasimhan, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Nature Publishing Group2015

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud

Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "ba ...

American Association for Cancer Research2015

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

Michael Vincent Frochaux, Bart Deplancke, Johan Auwerx, Pénélope Andreux, Evan Graehl Williams, Laurent Mouchiroud

The BXD genetic reference population is a recombinant inbred panel descended from crosses between the C57BL/6 (B6) and DBA/2 (D2) strains of mice, which segregate for about 5 million sequence variants. Recently, some of these variants have been established ...

Public Library of Science2014

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Kristina Schoonjans, Johan Auwerx, Carlos Canto Alvarez, Norman Lionel Moullan, Evan Graehl Williams, Eija Riitta Pirinen, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Cell Press2014

Transcriptional Coregulators: Fine-Tuning Metabolism

Johan Auwerx, Laurent Mouchiroud

Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptio ...

Cell Press2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Laurent Mouchiroud, Giuseppe Lo Sasso, Alessandra Piersigilli

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Marie-Pierre Meurville, Laurent Mouchiroud, Govindan Narayanan Krishnamani

2014

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Johan Auwerx, Laurent Mouchiroud, Virginija Jovaisaite

The ability to respond to various intracellular and/or extracellular stresses allows the organism to adapt to changing environmental conditions and drives evolution. It is now well accepted that a progressive decline of the efficiency of stress response pa ...

Company of Biologists2014

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Sabrina Bichet, Johan Auwerx, Richardus Houtkooper, Norman Lionel Moullan, Pénélope Andreux, Adrienne Joëlle Laurence Mottis, Laurent Mouchiroud, Virginija Jovaisaite, Xu Wang

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Marie-Pierre Meurville, Laurent Mouchiroud, Govindan Narayanan Krishnamani

We describe a microfluidic platform for the automated culture, treatment and long-term highresolution imaging of Caenorhabditis elegans nematodes under normal physiological conditions. Our device features: (i) a microfluidic design tailored for the isolati ...

2014

Mitonuclear protein imbalance as a conserved longevity mechanism

Graham Knott, Elena Katsyuba, Johan Auwerx, Richardus Houtkooper, Norman Lionel Moullan, Dongryeol Ryu, Laurent Mouchiroud

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Methods of treating mitochondrial dysfunction

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging. ...

2013

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Laurent Mouchiroud

Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge ...

Cold Spring Harbor Laboratory Press2013

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

Ncor1 is a physiological modulator of muscle mass and oxidative function

Johan Auwerx, Hiroyasu Yamamoto, Laurent Mouchiroud

The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic ...

2012

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

Kristina Schoonjans, Johan Auwerx, Carlos Canto Alvarez, Hiroyasu Yamamoto, Evan Graehl Williams, Laurent Mouchiroud

Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enha ...

2011

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