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Stéphanie Lacour

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Publications associées (122)

Radiation Performance of Antennas Implanted in Small Animals for Neuroengineering

Anja Skrivervik, Stéphanie Lacour, James Daniel Rosenthal, Mingxiang Gao, Kangling Wu, Zvonimir Sipus

Wireless data communication could improve the performance and reliability of biomedical implants used in fundamental neuroscience research by removing infection-prone transcutaneous cabling. The small size of common research animals like mice and rodents, ...

IEEE2023

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Florent-Valéry Coen, Alix Esther Anne Trouillet

Interfacing the human body with the next generation of electronics requires technological advancement in designing and producing bioelectronic circuits. These circuits must integrate electrical functionality while simultaneously addressing limitations in m ...

2023

Neural Stimulation Hardware for the Selective Intrafascicular Modulation of the Vagus Nerve

Stéphanie Lacour, Silvestro Micera, Valentina Marie Paggi

The neural stimulation of the vagus nerve is able to modulate various functions of the parasympathetic response in different organs. The stimulation of the vagus nerve is a promising approach to treating inflammatory diseases, obesity, diabetes, heart fail ...

Ieee-Inst Electrical Electronics Engineers Inc2023

Radiation Patterns of RF Wireless Devices Implanted in Small Animals: Unexpected Deformations Due to Body Resonance

Anja Skrivervik, Stéphanie Lacour, James Daniel Rosenthal, Mingxiang Gao, Kangling Wu, Zvonimir Sipus, German Augusto Ramirez Arroyave

One challenge in designing RF wireless bioelectronic devices is the impact of the interaction between electromagnetic waves and host body tissues on far-field wireless performance. In this paper, we investigate a peculiar phenomenon of implantable RF wirel ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Deployment of an electrocorticography system with a soft robotic actuator

Florian Dylan Fallegger, Stéphanie Lacour, Sukho Song, Kyungjin Kim, Alix Esther Anne Trouillet

Electrocorticography (ECoG) is a minimally invasive approach frequently used clinically to map epileptogenic regions of the brain and facilitate lesion resection surgery and increasingly explored in brain-machine interface applications. Current devices dis ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Florian Dylan Fallegger, Stéphanie Lacour, Alix Esther Anne Trouillet

Neurological impairments and diseases can be diagnosed or treated using electrocorticography (ECoG) arrays. In drug-resistant epilepsy, these help delineate the epileptic region to resect. In long-term applications such as brain-computer interfaces, these ...

JOURNAL OF VISUALIZED EXPERIMENTS2023

A stretchable sensor for force estimation in soft wearable robots

Stéphanie Lacour, Haotian Chen

Soft wearable robots to assist human movements, such as exosuits, have rapidly gained attention thanks to their compliance, low weight and accessibility. However, force measurement in exosuits still rely on load cells and rigid sensors that are not wearabl ...

IEEE2022

A finite element model of the mechanical interactions between peripheral nerves and intrafascicular implants

Stéphanie Lacour, Silvestro Micera, Outman Akouissi

Objective. Intrafascicular peripheral nerve implants are key components in the development of bidirectional neuroprostheses such as touch-enabled bionic limbs for amputees. However, the durability of such interfaces is hindered by the immune response follo ...

IOP Publishing Ltd2022

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Léonie Asboth, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Noaf Salah Ali Alwahab, Ivan Furfaro, Ileana Ozana Jelescu, Andreas Rowald, Claudia Kathe, Valentina Marie Paggi, Jimmy James Ravier, Kyungjin Kim, Thomas Haynes Hutson

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Tomislav Milekovic, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Katia Galan, Jocelyne Bloch, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

A 16-Channel Neural Recording System-on-Chip With CHT Feature Extraction Processor in 65-nm CMOS

Catherine Dehollain, Yusuf Leblebici, Volkan Cevher, Florian Dylan Fallegger, Stéphanie Lacour, Cosimo Aprile, Kerim Türe, Emilie Cornelia Maria Revol, Arda Uran, Alix Esther Anne Trouillet

Next generation invasive neural interfaces require fully implantable wireless systems that can record from a large number of channels simultaneously. However, transferring the recorded data from the implant to an external receiver emerges as a significant ...

2022

Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)

Nicolas Vachicouras, Stéphanie Lacour, Florent-Valéry Coen

The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides hearing to deaf patients by electrically stimulating the cochlear nucleus (CN) of the brainstem. Whether such stimulation activates one or the other of the CN's two major sub ...

SPRINGER2022

NeuralTree: A 256-Channel 0.227-mu J/Class Versatile Neural Activity Classification and Closed-Loop Neuromodulation SoC

Mahsa Shoaran, Stéphanie Lacour, Emilie Cornelia Maria Revol, Alix Esther Anne Trouillet, Cong Ding, Uisub Shin, Bingzhao Zhu

Closed-loop neural interfaces with on-chip machine learning can detect and suppress disease symptoms in neurological disorders or restore lost functions in paralyzed patients. While high-density neural recording can provide rich neural activity information ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures

Stéphanie Lacour

Cardiomyocyte cultures exhibit spontaneous electrical and contractile activity, as in a natural cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to those of heart rate variability in vivo. Mechanical deformations and ...

WILEY2022

Recent Advances in Encapsulation of Flexible Bioelectronic Implants: Materials, Technologies, and Characterization Methods

Yves Leterrier, Stéphanie Lacour, Kyungjin Kim, Kangling Wu, Massimo Mariello

Bioelectronic implantable systems (BIS) targeting biomedical and clinical research should combine long-term performance and biointegration in vivo. Here, recent advances in novel encapsulations to protect flexible versions of such systems from the surround ...

Wiley-V C H Verlag Gmbh2022

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Stéphanie Lacour

Fibrotic scarring secondary to the foreign body reaction (FBR) generates a physical barrier obstructing the functional interaction of implantable medical devices with the host tissue. The mechanistic basis of the FBR is poorly understood, restricting the c ...

National Academy of Sciences2022

Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies

Stéphanie Lacour, Florent-Valéry Coen, Silvestro Micera, Grégoire Courtine, Selin Anil, Quentin Barraud, Newton Cho, Nicholas David James

Numerous neurorehabilitative, neuroprosthetic, and repair interventions aim to address the consequences of upper limb impairments after neurological disorders. Although these therapies target widely different mechanisms, they share the common need for a pr ...

AMER ASSOC ADVANCEMENT SCIENCE2022

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