Publications de Fabio Mario Spiga

Label-Free Detection of Tobramycin in Serum by Transmission-Localized Surface Plasmon Resonance

Laurent Décosterd, Thierry Buclin, Carlotta Guiducci, Anna Ferretti, Giulia Cappi, Fabio Mario Spiga, Michael Beyeler

In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted to the actual needs of each patient in a truly personalized medicine approach. Key for widespread dosage adjustment is the availability of point-of-care devices abl ...

Amer Chemical Soc2015

More DNA–Aptamers for Small Drugs: A Capture–SELEX Coupled with Surface Plasmon Resonance and High-Throughput Sequencing

Carlotta Guiducci, Fabio Mario Spiga

To address limitations in the production of DNA aptamers against small molecules, we introduce a DNA-based capture-SELEX (systematic evolution of ligands by exponential enrichment) protocol with long and continuous randomized library for more flexibility, ...

ACS Publications2015

Hybridization chain reaction performed on a metal surface as a means of signal amplification in SPR and electrochemical biosensors

Carlotta Guiducci, Giampaolo Zuccheri, Fabio Mario Spiga

A more specific and intense signal is desirable for most kinds of biosensors for biomedical or environmental applications, and it is especially so for label-free biosensors. In this paper, we show that hybridization chain reaction (HCR) can be exploited fo ...

Elsevier2014

Another transistor-based revolution: on-chip qPCR

Carlotta Guiducci, Fabio Mario Spiga

More than 40 years after the invention of semiconductor pH microtransducers known as ISFETs, this transistor-based technology may revolutionize quantitative PCR. ...

Nature Publishing Group2013

Digital approaches in Electronic biochips

Enrico Accastelli, Carlotta Guiducci, Fabio Mario Spiga

Download Citation Email Print Request Permissions Save to Project Electronic biochips are defined by the merge of integrated electronics, containing diverse sensors, with reaction solution and sample hold in reaction chamber(s). Based on their overall stru ...

IEEE2013

A Portable Setup for Molecular Detection by Transmission LSPR

Luca Benini, Enrico Accastelli, Carlotta Guiducci, Giulia Cappi, Fabio Mario Spiga

In the framework of bioanalytics and multiple array detection, we developed a fully portable and low-cost detection system based on Localized Surface Plasmon Resonance (LSPR) in a transmission configuration (T-LSPR). The transmission approach is suitable t ...

2012