Publications de Georgios Savoglidis

Control Theory Concepts for Modeling Uncertainty in Enzyme Kinetics of Biochemical Networks

Ljubisa Miskovic, Vassily Hatzimanikatis, Georgios Savoglidis, Milenko Tokic

Analysis of the dynamic and steady-state properties of biochemical networks hinges on information about the parameters of enzyme kinetics. The lack of experimental data characterizing enzyme activities and kinetics along with the associated uncertainties i ...

2019

Efficient cleavage of aryl ether C–O linkages by Rh–Ni and Ru–Ni nanoscale catalysts operating in water

Paul Joseph Dyson, Vassily Hatzimanikatis, Duncan Thomas Lindsay Alexander, Ning Yan, Antoine Philippe Van Muyden, Safak Bulut, Georgios Savoglidis, Sviatlana Siankevich

Bimetallic Ru–Ni and Rh–Ni nanocatalysts coated with a phase transfer agent efficiently cleave aryl ether C–O linkages in water in the presence of hydrogen. For dimeric substrates with weaker C–O linkages, i.e. α-O-4 and β-O-4 bonds, low loadings of the pr ...

2018

Ionic polymers and use thereof in processing of biomass

Paul Joseph Dyson, Zhaofu Fei, Georgios Savoglidis, Sviatlana Siankevich

The invention provides ionic polymers (IP) consisting of anions and a polymeric backbone containing cations. The invention also provides the ionic polymers incorporated in membranes or attached to solid supports and use of the ionic polymers in processing ...

2017

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

Paolo Angelino, Vassily Hatzimanikatis, Howard Riezman, Georgios Savoglidis

We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the met ...

Academic Press Inc Elsevier Science2016

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Vassily Hatzimanikatis, Patrick Alain Sandoz, Georgios Savoglidis, Tiziano Dallavilla

Cellular functions are largely regulated by reversible post-translational modifications of proteins which act as switches. Amongst these, S-palmitoylation is unique in that it confers hydrophobicity. Due to technical difficulties, the understanding of this ...

Public Library of Science2016

A novel platinum nanocatalyst for the oxidation of 5-Hydroxymethylfurfural into 2,5-Furandicarboxylic acid under mild conditions

Gabor Laurenczy, Paul Joseph Dyson, Zhaofu Fei, Duncan Thomas Lindsay Alexander, Ning Yan, Georgios Savoglidis, Sviatlana Siankevich

5-Hydroxymethylfurfural (HMF) is a key intermediate obtainable from various cellulosic (biomass) derivatives, but it must be converted to other chemicals such as 2,5-Furandicarboxylic acid (FDCA) for direct use. FDCA is an important derivative of HMF as it ...

Academic Press Inc Elsevier Science2014

Constant-yield control of continuous bioreactors

Georgios Savoglidis

The process of anaerobic digestion is a common application in the treatment of industrial and communal wastewater treatment plants. The biochemical reactions taking place inside the fermenter can be described by a system of first order differential equatio ...

Elsevier Science Sa2013