Giulia Palermo

Cette personne n’est plus à l’EPFL

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Publications associées (26)

Molecular dynamics and mutagenesis studies indicate structural flexibility as a key factor for substrate specificity in FAAH catalysis

Ursula Röthlisberger, Pablo Campomanes Ramos, Giulia Palermo, Andrea Cavalli

Amer Chemical Soc2014

Hydrolysis of anandamide in FAAH shows that nitrogen inversion is key to efficient enzyme-assisted amide bond cleavage

Ursula Röthlisberger, Pablo Campomanes Ramos, Giulia Palermo, Andrea Cavalli

Amer Chemical Soc2014

Wagging the Tail: Essential Role of Substrate Flexibility in FAAH Catalysis

Ursula Röthlisberger, Marilisa Neri, Pablo Campomanes Ramos, Giulia Palermo, Andrea Cavalli

The serine hydrolase, fatty acid amide hydrolase (FAAH), is responsible for the intracellular degradation of anandamide and other bioactive fatty acid ethanolamides involved in the regulation of pain, inflammation, and other pathophysiological processes. T ...

Amer Chemical Soc2013

Dynamics of catalytic metals during DNA cleavage in type II topoisomerase

Matteo Dal Peraro, Marco Stenta, Giulia Palermo, Andrea Cavalli

Amer Chemical Soc2013

Fatty acid amide hydrolase (FAAH) substrate specificity understood via molecular dynamics

Ursula Röthlisberger, Marilisa Neri, Pablo Campomanes Ramos, Giulia Palermo, Andrea Cavalli

Amer Chemical Soc2013

Pushing the Frontiers of First-Principles Based Computer Simulations of Chemical and Biological Systems

Ursula Röthlisberger, Ivano Tavernelli, Basile Curchod, Marilisa Neri, Pablo Campomanes Ramos, Stefano Vanni, Elizabeth Claire Brunk, Manuel Dömer, Andrey Laktionov, Negar Ashari Astani, Polydefkis Diamantis, Thomas James Penfold, Giulia Palermo

The Laboratory of Computational Chemistry and Biochemistry is active in the development and application of first-principles based simulations of complex chemical and biochemical phenomena. Here, we review some of our recent efforts in extending these metho ...

2011

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