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Silvestro Micera

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Publications associées (314)

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

Silvestro Micera

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

Aip Publishing2024

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System

Silvestro Micera

Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...

Wiley2024

A computational model to design wide field-of-view optic nerve neuroprostheses

Silvestro Micera, Simone Romeni, Gabriele Marino

Retinal stimulation (RS) allows restoring vision in blind patients, but it covers only a narrow region of the visual field. Optic nerve stimulation (ONS) has the potential to produce visual perceptions spanning the whole visual field, but it produces very ...

CELL PRESS2024

Characterization of a Conductive Hydrogel@carbon Fibers Electrode as a Novel Intraneural Interface

Silvestro Micera

Peripheral neural interfaces facilitate bidirectional communication between the nervous system and external devices, enabling precise control for prosthetic limbs, sensory feedback systems, and therapeutic interventions in the field of Bioelectronic Medici ...

SPRINGERNATURE2024

Decoding Lower Limb Motor Attempts from EEG Signals in a Spinal Cord Injury Patient with Epidural Electrical Implant

Silvestro Micera, Vincent Alexandre Mendez, Leonardo Pollina

Epidural electrical stimulation (EES) has been employed to restore motor functions in the lower limbs of patients with spinal cord injuries (SCIs). However, non-invasive methods for controlling this stimulation have not yet been explored. This study aims t ...

Springer Science and Business Media Deutschland GmbH2024

Remapping Wetness Perception in Upper Limb Amputees

Solaiman Shokur, Silvestro Micera, Jonathan Louis Muheim, Outman Akouissi

Recent research has made remarkable strides in restoring sensory feedback for prosthetic users, including tactile, proprioceptive, and thermal feedback. Herein, a sensory modality that has been largely neglected is explored: the ability to perceive wetness ...

Wiley2024

Thermal sensing device and sensory feedback system and method using such thermal sensing device

Solaiman Shokur, Silvestro Micera, Jonathan Louis Muheim, Outman Akouissi, Francesco Iberite

The present invention concerns a thermal sensing device (1) and a sensory feedback system and method using such thermal sensing device, comprising at least one film (19) of electrically insulating polymer defining a global surface of the thermal sensing de ...

2024

Our research path toward the restoration of natural sensations in hand prostheses

Solaiman Shokur, Silvestro Micera

The human hand, with its intricate sensory capabilities, plays a pivotal role in our daily interactions with the world. This remarkable organ possesses a wide range of natural sensors that enrich our experiences, enabling us to perceive touch, position, an ...

2024

Stroke Recovery–Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Philip Egger, Sylvain Jean-François Harquel, Silvestro Micera, Elena Beanato, Takuya Morishita, Giorgia Giulia Evangelista, Pauline Menoud, Lisa Aïcha Mireille Julie Fleury

BACKGROUND: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial m ...

Ovid Technologies (Wolters Kluwer Health)2024

Cardiovascular Response to Intraneural Right Vagus Nerve Stimulation in Adult Minipig

Stéphanie Lacour, Silvestro Micera, Valentina Marie Paggi

Objective: This study explored intraneural stimulation of the right thoracic vagus nerve (VN) in sexually mature male minipigs to modulate safe heart rate and blood pressure response. Material and Methods: We employed an intraneural electrode designed for ...

ELSEVIER2024

Beyond the limiting gap length: peripheral nerve regeneration through implantable nerve guidance conduits

Francesco Stellacci, Silvestro Micera

Peripheral nerve damage results in the loss of sensorimotor and autonomic functions, which is a significant burden to patients. Furthermore, nerve injuries greater than the limiting gap length require surgical repair. Although autografts are the preferred ...

Royal Soc Chemistry2024

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Silvestro Micera, Simone Romeni, Luca Pierantoni, Gabriele Marino

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

IEEE2023

Classification of patients with cardiac amyloidosis using machine learning models on Italian electronic clinical health records

Silvestro Micera, Sara Mazzucato

Amyloidosis refers to a range of medical conditions in which misshapen proteins accumulate in various organs and tissues, forming insoluble fibrils. Cardiac amyloidosis is frequently linked to the buildup of misfolded transthyretin (TTR) or immunoglobulin ...

IEEE2023

Modulation of brain signals during sensorimotor and imaging tasks in a person with an implanted upper-limb prosthesis following amputation of the left hand Analysis of amputee's sensory-motor activity

Fabrizio Vecchio, Silvestro Micera

Elsevier France-Editions Scientifiques Medicales Elsevier2023

Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer's Disease continuum?

Silvestro Micera, Michael Lassi

Alzheimer's disease (AD) pathological changes may begin up to decades earlier than the appearance of the first symptoms of cognitive decline. Subjective cognitive decline (SCD) could be the first pre-clinical sign of possible AD, which might be followed by ...

ELSEVIER SCI LTD2023

Restoration of natural thermal sensation in upper-limb amputees

Solaiman Shokur, Simon Gallo, Giulio Rognini, Silvestro Micera, Jonathan Louis Muheim, Outman Akouissi

The use of hands for gathering rich sensory information is essential for proper interaction with the environment; therefore, the restoration of sensation is critical for reestablishing the sense of embodiment in hand amputees. Here, we show that a noninvas ...

American Association for the Advancement of Science2023

Human-machine interface for two-dimensional steering control with the auricular muscles

Solaiman Shokur, Silvestro Micera, Daniel Jose Lins Leal Pinheiro

Human-machine interfaces (HMIs) can be used to decode a user's motor intention to control an external device. People that suffer from motor disabilities, such as spinal cord injury, can benefit from the uses of these interfaces. While many solutions can be ...

FRONTIERS MEDIA SA2023

Bringing sensation to prosthetic hands-chronic assessment of implanted thin-film electrodes in humans

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Ivo Strauss, Giacomo Valle

Direct stimulation of peripheral nerves with implantable electrodes successfully provided sensory feedback to amputees while using hand prostheses. Longevity of the electrodes is key to success, which we have improved for the polyimide-based transverse int ...

2023

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Silvestro Micera, Simone Romeni, Bianca Ziliotto

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

IEEE2023

Sensory-Motor Neurostimulation to Enhance Exosuit Performance

Silvestro Micera, Stanisa Raspopovic, Andrea Crema, Giacomo Valle

Exosuits typically provide limited mechanical support and rely on a user's residual functional ability. However, people with neurological impairments often suffer from both motor and sensory deficits that limit the assistance an exosuit can provide. To ove ...

IEEE2023

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