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Tina Riedel

Cette personne n’est plus à l’EPFL

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Publications associées (39)

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

Paul Joseph Dyson, Emilia Paunescu, Tina Riedel

Four arene osmium complexes were prepared containing derivatives of ethacrynic acid, a potent inhibitor of glutathione Stransferases, either by direct coordination or via N- or P-donor ligands. The complexes were characterized by spectroscopic and analytic ...

American Chemical Society2016

Synthesis, Structure, and Anticancer Activity of Arene-Ruthenium(II) Complexes with Acylpyrazolones Bearing Aliphatic Groups in the Acyl Moiety

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel

A series of neutral ruthenium(II) arene complexes [(arene)Ru(Q(R))Cl] (arene = p-cymene (cym) or hexamethylbenzene (hmb)) containing 4-acyl-5-pyrazolonate Q(R) ligands with different electronic and steric substituents (R = 4-cyclohexyl, 4-stearoyl, or 4-ad ...

American Chemical Society2016

Dinuclear arene ruthenium thiolato complexes with fluorous side-chains

Paul Joseph Dyson, Tina Riedel

Four complexes of the general formula (eta(6)-p-MeC6H4Pri)(2)Ru-2(mu-SC2H4R)(3), R = (CF2)(7)CF3 (1), (CF2)(5)CF3 (2), (CF2)(3)CF3 (3) and (CH2)(5)CH3 (4) were synthesized and characterized. The molecular structures of complexes 1 and 3 were confirmed ...

Elsevier Science Sa2016

Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers

Paul Joseph Dyson, Tina Riedel

A series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-L)(2)(mu(4)-OO boolean AND OO)(2)]CF3SO3 (L-1 = N,N'-bis(4-pyridylmethyl)-pyromellitic diimide, L-2 = N,N'-bis(4-pyridylmethyl)-naphthalene diimide) wer ...

Elsevier2016

Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance

Paul Joseph Dyson, Tina Riedel, Mylène Soudani

Tetranuclear arene ruthenium complexes of the general formula {Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4) ...

Elsevier Science Sa2016

From Sunscreen to Anticancer Agent: Ruthenium(II) Arene Avobenzone Complexes Display Potent Anticancer Activity

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel, Agnese Petrini

A series of ruthenium(II) arene derivatives (arene = cymene (cym), hexamethylbenzene (hmb)) containing avobenzone (1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AVBH) and PTA (1,3,5-triaza-7-phosphaadamantane) or PTA-Me (N-methyl-1,3,5-triaz ...

American Chemical Society2016

Organometallic rhodium(III) and iridium(III) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel, Agnese Petrini

A series of half-sandwich cyclopentadienyl rhodium(III) and iridium(III) complexes of the type [CpM(curc/bdcurc) Cl] and [CpM(curc/bdcurc)(PTA)][SO3CF3], in which Cp* = pentamethylcyclopentadienyl, curcH = curcumin and bdcurcH = bisdemethoxycurcumin as O ...

2015

Synthesis of Triazenes with Nitrous Oxide

Kay Severin, Rosario Scopelliti, Paul Joseph Dyson, Gregor Kiefer, Tina Riedel

Triazenes are valuable compounds in organic chemistry and numerous applications have been reported. Furthermore, triazenes have been investigated extensively as potential antitumor drugs. Here, we describe a new method for the synthesis of triazenes. The p ...

Wiley-Blackwell2015

Molecular Mechanism of Ruthenium and Gold Anticancer Agents in the Allosteric Regulation of the Histone Proteins of Chromatin

Paul Joseph Dyson, Ursula Röthlisberger, Giulia Palermo, Tina Riedel

Cell Press2015

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

Paul Joseph Dyson, Tina Riedel, Gianni Sava

Aim of the study The tumor metastases targeting ruthenium complex NAMI-A synergistically improves the activity of gemcitabine in combination therapies. High-throughput screening was used to identify other potential drug combinations from a library of FDA a ...

Springer2015

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

Paul Joseph Dyson, Emilia Paunescu, Tina Riedel

Pyridine- and phosphine-based ligands modified with ethacrynic acid (a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes and to a ruthenium(III) NAMI-A type complex. All the compounds (ligands an ...

Amer Chemical Soc2015

Iridium-Stabilized pi-Selenocyclohexadienyls: Synthesis, Molecular Structure, and Cytotoxicity

Paul Joseph Dyson, Tina Riedel

A series of iridium-stabilized selenocyclohexadienyls of general formula [CpIr((5)-C6H5-nMenSe)][BF4] {Cp = (5)-C5Me5, n = 0, n = 1, and n = 3} is described, with the selenocyclohexadienyl unit being isolated for the first time by -coordination to a Cp*I ...

Georg Thieme Verlag Kg2015

Higher generation cationic N,N-ruthenium(II)-ethylene-glycol-derived metallodendrimers: Synthesis, characterization and cytotoxicity

Paul Joseph Dyson, Tina Riedel

A new series of higher generation cationic N,N-chelating, ruthenium(II)-ethylene-glycol metallodendrimers from first-, second-, third- and fourth-generation pyridylimine-based poly(propylene) dendrimer scaffolds of the type, DAB-(NH2) (where n = 4, 8, 16 o ...

Elsevier Science Sa2015

Ruthenium(II)-Arene RAPTA Type Complexes Containing Curcunnin and Bisdemethoxycurcumin Display Potent and Selective Anticancer Activity

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel

A series of novel ruthenium(II) arene RAPTA type derivatives (arene = cymene, hexamethylbenzene) containing curcumin-based ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and PTA (1,3,5-triaza-7-phosphaadamantane) have been synthesized and fully ...

2014

Synthesis, structural characterization and cytotoxicity of bimetallic chlorogold(I) phosphine complexes employing functionalized phosphinoferrocene carboxamides

Paul Joseph Dyson, Tina Riedel

Gold( I) phosphine complexes of the general formula [AuCl(Ph(2)PfcCONHY-kappa P)], where Y is CH2CO2Me (7), CH2CONH2 (8), CH2CH2OH (9), CH(CH2OH)(2) (10), C(CH2OH)(3) (11), and CH2SO3(HNEt3) (12), and fc is ferrocene-1,1'-diyl, were prepared from [AuCl(tht ...

Elsevier Science Sa2014

Strategy to Optimize the Biological Activity of Arene Ruthenium Metalla-Assemblies

Paul Joseph Dyson, Tina Riedel

Three new dinuclear arene ruthenium metalla-clips of the general formula [(p-cymene)(2)Ru2Cl2(mu-L)] have been prepared from {(p-cymene)(2)Ru2Cl2(p-Cl)(2)] and H2L organic linkers (H2La = diethyl-1,2-diazeneclicarboxylate, H2Lb = N,N'-bis(2-hydroxyethyl)ox ...

Amer Chemical Soc2014

Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents

Paul Joseph Dyson, Tina Riedel

New polynuclear organometallic Platinum Group Metal (PGM) complexes containing di- and tripyridyl ester ligands have been synthesised and characterised using analytical and spectroscopic techniques including H-1, C-13 NMR and infrared spectroscopy. Reactio ...

2014

Arene ruthenium and pentamethylcyclopentadienyl rhodium and iridium complexes containing N,O-chelating ligands derived from piroxicam: Synthesis, molecular structure and cytotoxicity

Paul Joseph Dyson, Tina Riedel

The non-steroidal anti-inflammatory and anti-arthritic drug piroxicam (LH) reacts with arene ruthenium dichloride dimers in refluxing dichloromethane to give the complexes [(eta(6)-arene)Ru(eta(2)-N,O-L)Cl] (3: arene = C6H5Me, 4: arene = p-MeC6H4Pri, 5: ar ...

Elsevier2014

Ruthenium(II) and osmium(II) 1,2,3-triazolylidene organometallics: a preliminary investigation into the biological activity of 'click' carbene complexes

Paul Joseph Dyson, Stéphanie Crot, Kelly Joan Kilpin, Tina Riedel

Taking advantage of the facile and versatile synthetic properties of 'click' 1,2,3-triazolylidene N-heterocyclic carbenes (tzNHC's), a range of new organometallic Ru(II) and Os(II) arene complexes containing functionalised tzNHC ligands, [M(eta(6)-p-cymene ...

2014

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