Publications de Wareed Ahmed | EPFL Graph Search

Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops

Joachim Lingner, Wareed Ahmed, Thomas Frédéric Lunardi, Thu Trang Nguyen, Eftychia Kyriacou

Telomeres are the nucleoprotein structures at chromosome ends. Telomeres are particularly sensitive to oxidative stress, which can induce telomere damage, shortening, and premature cellular senescence. How oxidative damage influences telomere structure has ...

2025

PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage

Joachim Lingner, Wareed Ahmed

Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA breaks (SSBs). The peroxired ...

2020

SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres

Joachim Lingner, Verena Pfeiffer, Wareed Ahmed, Aleksandra Vancevska, Marianna Feretzaki

Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and DNA damage repair, and mutations in SMCHD1 can cause facioscapulohumeral muscular dystrophy. More re ...

WILEY2020

PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase

Joachim Lingner, Wareed Ahmed

Cold Spring Harbor Laboratory Press2018

Impact of oxidative stress on telomere biology

Joachim Lingner, Wareed Ahmed

2018

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

Stewart Cole, Claudia Sala, Wareed Ahmed

Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind i ...

Public Library Science2017

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

Joachim Lingner, Viesturs Simanis, Sophie Redon, Eric Aeby, Wareed Ahmed

Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show th ...

Elsevier2016