Publications de Orbicia Riccio Wicht

Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Vandana Veenit, Olivia Zanoletti, Jocelin Grosse, Orbicia Riccio Wicht

Despite the enormous negative impact of excessive aggression for individuals and societies, there is a paucity of treatments. Here, using a peripubertal stress model of heightened aggression in rats, we investigated the involvement of the glucocorticoid sy ...

2019

Neuroligin-2 expression in the prefrontal cortex is involved in attention deficits induced by peripubertal stress

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Olivia Zanoletti, Jocelin Grosse, Orbicia Riccio Wicht

Emerging evidence indicates that attention deficits, which are frequently observed as core symptoms of neuropsychiatric disorders, may be elicited by early life stress. However, the mechanisms mediating these stress effects remain unknown. The prefrontal c ...

2016

Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Orbicia Riccio Wicht

Early-life stress is a critical risk factor for developing psychopathological alterations later in life. This early adverse environment has been modeled in rats by exposure to stress during the peripubertal period-that is, corresponding to childhood and pu ...

Nature Publishing Group2014

CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors

Maria del Carmen Sandi Perez, Vandana Veenit, Orbicia Riccio Wicht

Stressful life events during childhood and adolescence are important risk factors for the development of psychopathologies later in life. The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between earl ...

Pergamon-Elsevier Science Ltd2014

Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Céline Fournier, Orbicia Riccio Wicht

Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional be ...

Public Library of Science2013

The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Céline Fournier, Orbicia Riccio Wicht

The neural cell adhesion molecule (NCAM) is a key regulator of brain plasticity. Substantial evidence indicates that NCAM is down-regulated by exposure to sustained stress and chronic stress seems to lead to increased aggression. In addition, constitutiona ...

Informa Healthcare2013

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

Freddy Radtke, April Bezdek Pomey, Luca Pellegrinet, Orbicia Riccio Wicht

The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice. We found that Notch1 and Notch2 receptors function redund ...

2008