Publications de Pan Xu | EPFL Graph Search

Challenges of COVID-19 Case Forecasting in the US, 2020-2021

Joseph Chadi Benoit Lemaitre, Pan Xu, Myungjin Kim, Shan Yu, Lei Gao, Weitong Zhang, Wei Cao, Xinyi Li

During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies, and ...

Public Library Science2024

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Kristina Schoonjans, Johan Auwerx, Pan Xu

Aims: Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect of SIRT7 on sorafenib acquired resistance remains unclear and a possible anti-tumor mechanism bey ...

2024

A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model

Ruedi Aebersold, Kristina Schoonjans, Evan Graehl Williams, Pan Xu, Amir Banaei Esfahani, Vera Monica Lemos Da Silva, Chen Li

To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules loc ...

Nature Research2019

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Dongryeol Ryu, Maaike Hélène Oosterveer, Pan Xu, Xu Wang, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) ...

Amer Soc Clinical Investigation Inc2017

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Arnaud Comment, Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Norman Lionel Moullan, Dongryeol Ryu, Maaike Hélène Oosterveer, Emine Can, Pan Xu, Xu Wang, Hadrien Charles Edouard Demagny

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...

Cold Spring Harbor Laboratory2016

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

Pan Xu

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Gaining insight into the molecular pathways involved in the development of HCC is hence a prerequisite to design and develop novel and effective therapeutic strategies. ...

EPFL2016

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Chikage Mataki, Dongryeol Ryu, Maaike Hélène Oosterveer, Pan Xu, Keir Joe Menzies, Alessia Perino, Xu Wang, Vera Monica Lemos Da Silva

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014