Publications de Nikolaus Wenger

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Capogrosso, Jocelyne Bloch

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2019

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Jérôme Gandar, Stéphanie Lacour, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Bonizzato, Eduardo Martin Moraud

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

2018

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Capogrosso, Jocelyne Bloch

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2017

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Léonie Asboth, Jérôme Gandar, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Rubia van den Brand, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Julie Kreider, Laetitia Danielle Philippine Baud, Andrea Mortera, Jocelyne Bloch

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Bonizzato, Eduardo Martin Moraud

The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

2016

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Tomislav Milekovic, Léonie Asboth, Jérôme Gandar, Nicolas Vachicouras, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Stanisa Raspopovic, Marco Bonizzato, Eduardo Martin Moraud, Pavel Musienko

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

American Association for the Advancement of Science2014

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant, Eduardo Martin Moraud, Pavel Musienko, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Neuroprosthetic system to restore locomotion after neuromotor disorder

Nikolaus Wenger

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with Spinal Cord Injury (SCI) and Parkinson disease. Stimulation parameters are tuned manually and remain constant during motor execution which is suboptimal ...

EPFL2014

A real-time platform for studying the modulatory capacity of epidural stimulation after spinal cord injury

Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko

Epidural electrical stimulation (EES) showed promises to improve standing and walking after neurological disorders. To date, EES has been delivered continuously, although time-dependent stimulations would likely be more efficient to activate specific subse ...

Ieee2013

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Stanisa Raspopovic, Janine Beauparlant, Pavel Musienko, Marco Capogrosso

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

Society for Neuroscience2013