Publications de Hongbo Zhang | EPFL Graph Search

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Johan Auwerx, Hongbo Zhang, Hao Li, Vincenzo Sorrentino, Mario Romani, Changmyung Oh, Tanes Imamura de Lima

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like d ...

2021

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

Elena Katsyuba, Johan Auwerx, Hongbo Zhang

Protein lysine acetylation is a post-translational modification that regulates protein structure and function. It is targeted to proteins by lysine acetyltransferases (KATs) or removed by lysine deacetylases. This work identifies a role for the KAT enzyme ...

Rockefeller University Press2021

The gut microbiota influences skeletal muscle mass and function in mice

Walter Wahli, Johan Auwerx, Hongbo Zhang

The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...

AMER ASSOC ADVANCEMENT SCIENCE2019

The role of mitochondria in stem cell fate and aging

Johan Auwerx, Hongbo Zhang, Keir Joe Menzies

2018

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Stephan Morgenthaler, Kristina Schoonjans, Johan Auwerx, Maroun Bou Sleiman, Hongbo Zhang, Daria Rukina, Karim Laurent Gariani, Xu Wang, Tao Lin, Peiling Luan, Hao Li, Vincenzo Sorrentino, Qingyao Huang, Naveed Ziari

2018

Agents and methods using thereof for the prevention and treatment of stem cells senescence

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of stem senescence. ...

2017

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Adrian Schmid, Johan Auwerx, Norman Lionel Moullan, Hongbo Zhang, Solene Rietsch, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Francesca Potenza

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

2017

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

Abstract of the invention: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt ) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods ...

2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Elena Katsyuba, Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Alessia Perino, Karim Laurent Gariani, Vera Monica Lemos Da Silva, Pooja Jha, Jun Yong Kim

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Protein acetylation in metabolism - metabolites and cofactors

Elena Katsyuba, Johan Auwerx, Hongbo Zhang, Keir Joe Menzies

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...

Nature Publishing Group2016

Metabolic control of muscle and muscle stem cell function

Hongbo Zhang

Skeletal muscle composed of myofibers and a small amount of muscle stem cells (MuSCs). It plays important roles in energy metabolism. Some of the key metabolites, such as NAD+ and acetyl-CoA were recently found to regulate muscle and MuSCs function. Most o ...

EPFL2016

NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

Johan Auwerx, Carlos Canto Alvarez, Dongryeol Ryu, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Xu Wang, Vincenzo Sorrentino

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to ...

Amer Assoc Advancement Science2016

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Matthias Lütolf, Ruedi Aebersold, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Xu Wang, Peiling Luan, Davide D'Amico

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

Johan Auwerx, Hongbo Zhang

The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears ...

Elsevier2016

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Giuseppe Lo Sasso, Hongbo Zhang, Alessia Perino

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Kristina Schoonjans, Johan Auwerx, Carlos Canto Alvarez, Norman Lionel Moullan, Evan Graehl Williams, Eija Riitta Pirinen, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Cell Press2014