Publications de Mohammad Sadegh Saghafinia

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

Nadine Fournier, Douglas Hanahan, Krisztian Homicsko, Mohammad Sadegh Saghafinia, Dalya Ataca, Qiqun Zeng, Mélanie Louise Tichet, Yuqing Xie, Agnieszka Alicja Chryplewicz, Fleuriane Marie Tryskele Laurene Gallean, Jeremy Gilles Louis Guillot, Simge Yücel, Lucine Christe, Peng Zhang, Inti Zlobec

Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

American Association for the Advancement of Science2022

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression

Douglas Hanahan, Krisztian Homicsko, Stephan Wullschleger, Mohammad Sadegh Saghafinia, Iacovos Michael, Giovanni Ciriello

Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the origin of aggressive MLP tumors has been obscure. Herein, using multi-omics ap ...

AMER ASSOC CANCER RESEARCH2021

A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells

Mohammad Sadegh Saghafinia, Iacovos Michael

Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375 and YAP are res ...

NATURE RESEARCH2021

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

Mohammad Sadegh Saghafinia

Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...

EPFL2020

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Graham Knott, Douglas Hanahan, Mohammad Sadegh Saghafinia, Iacovos Michael, Qiqun Zeng, Brian Donal McCabe, Wei Jiao, Giovanni Ciriello, Peng Zhang, Inti Zlobec

Metastasis-the disseminated growth of tumours in distant organs-underlies cancer mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggressive basal-like subtype, but is also found at varying freq ...

2019

A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis

Douglas Hanahan, Mohammad Sadegh Saghafinia, Iacovos Michael

MicroRNA-mediated gene regulation has been implicated in various diseases, including cancer. This study examined the role of microRNAs (miRNAs) during tumorigenesis and malignant progression of pancreatic neuroendocrine tumors (PanNETs) in a genetically en ...

National Academy of Sciences2019

ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis

Nadine Fournier, Douglas Hanahan, Mohammad Sadegh Saghafinia, Iacovos Michael, Mélanie Louise Tichet

Herein, we report that the TGF beta superfamily receptor ALK7 is a suppressor of tumorigenesis and metastasis, as revealed by functional studies in mouse models of pancreatic neuroendocrine and lumina! breast cancer, complemented by experimental metastasis ...

Cell Press - Elsevier2019

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Douglas Hanahan, Marco Mina, Mohammad Sadegh Saghafinia, Giovanni Ciriello

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

2018

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Marco Mina, Franck Claude Raynaud, Mohammad Sadegh Saghafinia, Titouan Laessle, Elisa Oricchio, Elena Battistello, Stephanie Jocelyne Sungalee, Giovanni Ciriello, Daniele Tavernari

Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the ...

Cell Press2017