Publications de Martin Guillermo Mueller

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Martin Guillermo Mueller, Jeremy Pak Hei Wong

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyele ...

2020

Crowdbreaks: Tracking Health Trends Using Public Social Media Data and Crowdsourcing

Martin Guillermo Mueller, Marcel Salathé

In the past decade, tracking health trends using social media data has shown great promise, due to a powerful combination of massive adoption of social media around the world, and increasingly potent hardware and software that enables us to work with these ...

2019

In-situ strength of individual silicon particles within an aluminium casting alloy

Andreas Mortensen, Martin Guillermo Mueller, Goran Zagar

Measurements of local strength are performed in-situ on individual silicon particles that constitute the second phase of aluminium alloy A356. Particles are shaped using Focused Ion Beam (FIB) milling such that, upon the application of a compressive force ...

2018

Strength and fracture of silicon second-phase particles in aluminium casting alloys

Martin Guillermo Mueller

The mechanical behaviour of metallic materials that have a microstructure composed of a brittle phase embedded in a ductile matrix is dictated by a complex interplay of factors such as local phase properties, cohesive properties, geometrical characteristic ...

EPFL2017

Silicon particle pinhole defects in aluminium–silicon alloys

Andreas Mortensen, Martin Guillermo Mueller, Marta Fornabaio

It was recently shown that silicon particles in heat-treated Al–Si casting alloys can contain flaws such as surface pinholes and grooves, which cause varying degrees of reduction in the in situ particle fracture strength and hence influence the mechanical ...

Springer Verlag2017

Stable room-temperature micron-scale crack growth in single-crystalline silicon

Andreas Mortensen, Martin Guillermo Mueller, Goran Zagar

Room-temperature fracture along the (111) plane of silicon is probed at the micron-scale using chevron notched cantilever beams that enable stable crack growth before unstable fracture in successful tests. The main experimental observation is that a growin ...

2017

Microscopic strength of silicon particles in an aluminium–silicon alloy

Andreas Mortensen, Martin Guillermo Mueller, Goran Zagar, Marta Fornabaio

A microscopic three-point bending test that measures the strength of faceted particles of high aspect ratio is developed and used to probe individual coarsened plate-like silicon particles extracted from the eutectic Al-12.6%Si alloy. Focused ion beam mill ...

Elsevier2016

Fracture toughness measurement in fused quartz using triangular chevron-notched micro-cantilevers

Andreas Mortensen, Lionel Michelet, Martin Guillermo Mueller, Václav Pejchal, Goran Zagar

We extend to flat surfaces the fracture toughness method presented in Acts Materialia vol. 86 (2015) p.385 and measure in this manner the fracture toughness of fused quartz. Tests give 0.67 +/- 0.01 MPa m(1/2) which agrees with earlier microscopic and macr ...

Elsevier2016

Fracture toughness testing of nanocrystalline alumina and fused quartz using chevron-notched microbeams

Andreas Mortensen, Marco Cantoni, Martin Guillermo Mueller, Václav Pejchal, Goran Zagar

We show that chevron-notched samples offer an attractive approach to the measurement of fracture toughness in micron-scale samples of brittle materials and use the method to characterize quartz and nanocrystalline alumina. Focused ion beam milling is used ...

Elsevier2015

The local strength of microscopic alumina reinforcements

Andreas Mortensen, Marco Cantoni, Andreas Rossoll, Martin Guillermo Mueller, Václav Pejchal, Goran Zagar

We measure, using an adaptation of a method designed for ceramic ball bearings, the local strength of a brittle second phase that serves to reinforce a metal. The method uses focused ion beam milling and a nanoindentation device, and is free of artifacts c ...

Elsevier2015

On measuring fracture toughness under load control in the presence of slow crack growth

Andreas Mortensen, Martin Guillermo Mueller, Václav Pejchal, Goran Zagar, Aparna Singh

The influence of slow crack growth in ceramics on the measurement of their fracture toughness under steadily increasing controlled load (as is generally practiced in microscale testing) is analyzed to identify conditions under which the phenomenon can caus ...

Elsevier2015

Interaction between Facilitation and Depression at a Large CNS Synapse Reveals Mechanisms of Short-Term Plasticity

Ralf Schneggenburger, Olexiy Kochubey, Martin Guillermo Mueller

The two fundamental forms of short-term plasticity, short-term depression and facilitation, coexist at most synapses, but little is known about their interaction. Here, we studied the interplay between short-term depression and facilitation at calyx of Hel ...

Society for Neuroscience2010

A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held

Ralf Schneggenburger, Martin Guillermo Mueller

Recent studies have suggested that transmitter release facilitation at synapses is largely mediated by presynaptic Ca2+ current facilitation, but the exact contribution of Ca2+ current facilitation has not been determined quantitatively. Here, we determine ...

2008