Publications de Fabrice Daniel Darbellay

CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length

Denis Duboule, Célia Corinne Renée Bochaton, Fabrice Daniel Darbellay, Lucille Delisle, Hocine Rekaik, Alexandre Gauthier Aurèle Mayran, Pierre Osteil

Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. Un ...

National Academy of Sciences2024

Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs

Fabrice Daniel Darbellay, Anamaria Necsulea

The functionality of long noncoding RNAs (lncRNAs) is disputed. In general, lncRNAs are under weak selective pressures, suggesting that the majority of lncRNAs may be nonfunctional. However, although some surveys showed negligible phenotypic effects upon l ...

OXFORD UNIV PRESS2020

Constrained Transcriptional Polarity In The Organization Of Mammalian Hox Gene Clusters

Denis Duboule, Saskia Joëlle Delpretti Anex, Célia Corinne Renée Bochaton, Fabrice Daniel Darbellay, Lucille Delisle, Jozsef Zakany

2019

Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster

Fabrice Daniel Darbellay

HOX transcription factors determine the identity of body regions along the rostro-caudal axis during bilaterian embryogenesis. In vertebrates Hox genes distinctively lie organized in dense clusters, each typically composed of a dozen paralogous transcripti ...

EPFL2018

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

Denis Duboule, Fabrice Daniel Darbellay, Anamaria Necsulea, Jozsef Zakany

During embryonic development, Hox genes participate in the building of a functional digestive system in metazoans, and genetic conditions involving these genes lead to important, sometimes lethal,growth retardation. Recently, this phenotype was obtained af ...

National Academy of Sciences2017

Hox Genes Regulation During Vertebrate Development and Evolution

Denis Duboule, Fabrice Daniel Darbellay, Jozsef Zakany

Elsevier Science Bv2017

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Denis Duboule, Fabrice Daniel Darbellay

Hox gene clusters of jaw vertebrates display a tight genomic organization, which has no equivalent in any other bilateria genomes sequenced thus far. It was previously argued that such a topological consolidation toward a condensed, metagenic structure was ...

Elsevier Academic Press Inc2016